Aging

Tag

Core Pathways of Aging

johnswentworth28 Mar 2021 0:31 UTC

277 points

130 comments22 min readLW link 1 review

Anti-Aging: State of the Art

JackH31 Dec 2020 19:07 UTC

375 points

176 comments11 min readLW link 1 review

Aging and the geroscience hypothesis

DirectedEvolution12 Jul 2023 7:16 UTC

56 points

14 comments5 min readLW link

Thoughts on being mortal

Joe Carlsmith1 Jan 2021 19:17 UTC

84 points

5 comments6 min readLW link

Why SENS makes sense

emanuele ascani22 Feb 2020 16:28 UTC

28 points

2 comments31 min readLW link

That’s Not How Epigenetic Modifications Work

johnswentworth24 May 2025 0:15 UTC

68 points

12 comments2 min readLW link

[Preprint for commenting] Fighting Aging as an Effective Altruism Cause

avturchin16 Apr 2018 13:55 UTC

9 points

5 comments1 min readLW link

Compression of morbidity

DirectedEvolution12 Jul 2023 15:26 UTC

12 points

0 comments3 min readLW link

Cryonics and Regret

MvB24 Jul 2023 9:16 UTC

193 points

37 comments2 min readLW link 1 review

Why We Age, Part 1: What ageing is and is not

willbradshaw24 May 2020 9:06 UTC

55 points

5 comments7 min readLW link

(apomorphic.com)

Should we vaccinate against PGBD5 which codes for a transposase?

ChristianKl8 Jun 2021 19:22 UTC

18 points

5 comments1 min readLW link

If you want to live longer, become President

Bezzi11 Feb 2022 23:14 UTC

8 points

11 comments7 min readLW link

Addendum to “Amyloid Plaques: Medical Goodhart, Chemical Streetlight”

J Bostock2 Sep 2021 17:42 UTC

10 points

1 comment2 min readLW link

Living Forever is Hard, part 2: Adult Longevity

gwern9 Sep 2011 18:52 UTC

20 points

11 comments2 min readLW link

Why We Age, Part 2: Non-adaptive theories

willbradshaw26 May 2020 17:41 UTC

89 points

22 comments11 min readLW link

(apomorphic.com)

Bryan Johnson and a search for healthy longevity

NancyLebovitz27 Jul 2024 15:28 UTC

18 points

17 comments1 min readLW link

Adaptive Immune System Aging

johnswentworth13 Mar 2020 3:47 UTC

76 points

9 comments3 min readLW link

(Anti)Aging 101

George3d612 Mar 2025 3:59 UTC

5 points

2 comments3 min readLW link

(cerebralab.com)

Second-order selection against the immortal

Malmesbury3 Dec 2021 5:01 UTC

45 points

47 comments6 min readLW link

Age changes what you care about

Dentin16 Oct 2022 15:36 UTC

142 points

37 comments2 min readLW link

Homeostasis and “Root Causes” in Aging

johnswentworth5 Jan 2020 18:43 UTC

87 points

25 comments3 min readLW link

[Question] Does anyone have an anki deck on ageing / rejuvenation biotechnology that they could share?

freedomandutility10 Oct 2021 16:54 UTC

1 point

0 comments1 min readLW link

Immortality: A Practical Guide

G0W5126 Jan 2015 16:17 UTC

54 points

62 comments36 min readLW link

Internet Literacy Atrophy

Elizabeth26 Dec 2021 12:30 UTC

111 points

49 comments3 min readLW link

(acesounderglass.com)

Prediction market: Will John Wentworth’s Gears of Aging series hold up in 2033?

tailcalled25 Feb 2023 20:15 UTC

15 points

4 comments1 min readLW link

(manifold.markets)

Highlights of Comparative and Evolutionary Aging

johnswentworth22 May 2020 17:01 UTC

57 points

10 comments2 min readLW link

Wormy the Worm

River Lewis21 May 2022 15:34 UTC

3 points

23 comments5 min readLW link

(heytraveler.substack.com)

Nightclubs in Heaven?

J Bostock5 Nov 2021 23:28 UTC

10 points

3 comments2 min readLW link

SENS and Givewell: Conversation between Holden Karnofsky and Aubrey de Grey

curiousepic5 Mar 2013 19:24 UTC

30 points

12 comments12 min readLW link

The Lens, Progerias and Polycausality

johnswentworth8 Mar 2020 17:53 UTC

72 points

8 comments3 min readLW link

[Question] Why is loss of muscle cells not considered one of the hallmarks of aging?

ChristianKl5 Jan 2021 14:19 UTC

11 points

9 comments1 min readLW link

Project Proposal: Gears of Aging

johnswentworth9 May 2020 18:47 UTC

58 points

43 comments7 min readLW link

Hypothesis: lab mice have more active transposons then wild mice

ChristianKl5 Jun 2021 12:36 UTC

20 points

14 comments1 min readLW link

How much should we value life?

Adam Zerner6 Sep 2021 22:30 UTC

30 points

25 comments38 min readLW link

Wrinkles

johnswentworth19 Nov 2019 22:59 UTC

81 points

14 comments4 min readLW link

Three Open Problems in Aging

johnswentworth7 Nov 2020 19:39 UTC

48 points

8 comments5 min readLW link

Here’s Why Indefinite Life Extension Will Never Work, Even Though it Does.

HomingHamster4 Jun 2024 18:48 UTC

−13 points

5 comments18 min readLW link

Naked mole-rats: A case study in biological weirdness

eukaryote19 May 2019 18:40 UTC

95 points

14 comments3 min readLW link

(eukaryotewritesblog.com)

Impact of aging research besides LEV

emanuele ascani6 Jun 2019 10:42 UTC

15 points

0 comments7 min readLW link

Aging: A Surprisingly Tractable Problem

Quinn8 Apr 2021 19:25 UTC

11 points

0 comments1 min readLW link

Aldix and the Book of Life

ville1 Jan 2024 17:23 UTC

1 point

0 comments4 min readLW link

(medium.com)

On the Evolvability of Biological Immortality

simon460328 Jul 2025 21:13 UTC

20 points

0 comments35 min readLW link

Do not miss the cutoff for immortality! There is a probability that you will live forever as an immortal superintelligent being and you can increase your odds by convincing others to make achieving the technological singularity as quickly and safely as possible the collective goal/project of all of humanity, Similar to “Fable of the Dragon-Tyrant.”

Oliver--Klozoff29 Jun 2023 3:45 UTC

1 point

0 comments28 min readLW link

Beyond Biomarkers: Understanding Multiscale Causality

Matěj Nekoranec7 Jul 2024 9:56 UTC

13 points

0 comments7 min readLW link

Lifeism in the midst of death

TobyBartels9 Dec 2012 13:28 UTC

97 points

19 comments4 min readLW link

(DIY) FMT for Anti-Aging & Biohacking

EternallyBlissful28 Nov 2022 15:49 UTC

26 points

10 comments6 min readLW link

Human performance, psychometry, and baseball statistics

Craig_Heldreth15 Oct 2010 13:13 UTC

33 points

21 comments6 min readLW link

Longevity interventions when young

George3d624 Jul 2020 11:25 UTC

45 points

17 comments39 min readLW link

(cerebralab.com)

[LINK] Larry = Harry sans magic? Google vs. Death

Shmi18 Sep 2013 16:49 UTC

36 points

55 comments1 min readLW link

The Fountain of Health: a First Principles Guide to Rejuvenation

PhilJackson7 Jan 2023 18:34 UTC

115 points

39 comments41 min readLW link

BHTV: de Grey and Yudkowsky

Eliezer Yudkowsky13 Dec 2008 15:28 UTC

10 points

12 comments1 min readLW link

In defense of the amyloid hypothesis

dsj14 Aug 2025 17:52 UTC

43 points

0 comments1 min readLW link

(www.astralcodexten.com)

Does Age Bring Wisdom?

Scott Alexander8 Nov 2017 7:20 UTC

39 points

9 comments4 min readLW link

(slatestarcodex.com)

[Question] Why rationalists are not much concerned about mortality?

SurvivalBias10 Feb 2022 0:11 UTC

18 points

92 comments1 min readLW link

Many life-saving drugs fail for lack of funding. But there’s a solution: desperate rich people

Mvolz12 Mar 2025 15:24 UTC

17 points

0 comments1 min readLW link

(www.theguardian.com)

An alarming fact about the anti-aging community

diegocaleiro16 Feb 2015 17:49 UTC

44 points

65 comments2 min readLW link

Book review: Age Later

PeterMcCluskey27 Oct 2020 4:21 UTC

28 points

4 comments4 min readLW link

(www.bayesianinvestor.com)

“The Singularity Is Nearer” by Ray Kurzweil—Review

Lavender8 Jul 2024 21:32 UTC

22 points

0 comments4 min readLW link

Introducing the Longevity Research Institute

sarahconstantin14 Dec 2018 20:20 UTC

79 points

11 comments1 min readLW link

(srconstantin.wordpress.com)

[Question] What to make of Aubrey de Grey’s prediction?

Rafael Harth28 Feb 2020 19:25 UTC

23 points

18 comments1 min readLW link

Introducing the Longevity Research Institute

sarahconstantin8 May 2018 3:30 UTC

54 points

20 comments1 min readLW link

(srconstantin.wordpress.com)

Living Forever is Hard, or, The Gompertz Curve

gwern17 May 2011 21:08 UTC

67 points

87 comments3 min readLW link

Why people want to die

PhilGoetz24 Aug 2015 20:13 UTC

94 points

174 comments2 min readLW link

Being a donor for Fecal Microbiota Transplants (FMT): Do good & earn easy money (up to 180k/y)

EternallyBlissful8 Jul 2022 6:17 UTC

36 points

26 comments8 min readLW link

(forum.effectivealtruism.org)

[linkpost] Project Blueprint: ‘Measuring and then maximally reversing the quantified biological age of my organs’

matteodimaio16 Nov 2021 2:48 UTC

2 points

0 comments1 min readLW link

Are healthy choices effective for improving live expectancy anymore?

Christopher King8 May 2023 21:25 UTC

4 points

4 comments1 min readLW link

If calorie restriction works in humans, should we have observed it already?

Mark_Eichenlaub24 Apr 2012 4:28 UTC

32 points

33 comments1 min readLW link

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