Aging

Tag

Core Pathways of Aging

johnswentworthMar 28, 2021, 12:31 AM

275 points

129 comments22 min readLW link 1 review

Anti-Aging: State of the Art

JackHDec 31, 2020, 7:07 PM

375 points

176 comments11 min readLW link 1 review

Aging and the geroscience hypothesis

DirectedEvolutionJul 12, 2023, 7:16 AM

54 points

14 comments5 min readLW link

Thoughts on being mortal

Joe CarlsmithJan 1, 2021, 7:17 PM

84 points

5 comments6 min readLW link

Why SENS makes sense

emanuele ascaniFeb 22, 2020, 4:28 PM

28 points

2 comments31 min readLW link

That’s Not How Epigenetic Modifications Work

johnswentworthMay 24, 2025, 12:15 AM

66 points

12 comments2 min readLW link

[Preprint for commenting] Fighting Aging as an Effective Altruism Cause

avturchinApr 16, 2018, 1:55 PM

9 points

5 comments1 min readLW link

Compression of morbidity

DirectedEvolutionJul 12, 2023, 3:26 PM

12 points

0 comments3 min readLW link

Cryonics and Regret

MvBJul 24, 2023, 9:16 AM

190 points

35 comments2 min readLW link 1 review

Why We Age, Part 1: What ageing is and is not

willbradshawMay 24, 2020, 9:06 AM

55 points

5 comments7 min readLW link

(apomorphic.com)

Should we vaccinate against PGBD5 which codes for a transposase?

ChristianKlJun 8, 2021, 7:22 PM

18 points

5 comments1 min readLW link

If you want to live longer, become President

BezziFeb 11, 2022, 11:14 PM

8 points

11 comments7 min readLW link

Addendum to “Amyloid Plaques: Medical Goodhart, Chemical Streetlight”

J BostockSep 2, 2021, 5:42 PM

10 points

1 comment2 min readLW link

Living Forever is Hard, part 2: Adult Longevity

gwernSep 9, 2011, 6:52 PM

20 points

11 comments2 min readLW link

Why We Age, Part 2: Non-adaptive theories

willbradshawMay 26, 2020, 5:41 PM

89 points

22 comments11 min readLW link

(apomorphic.com)

Bryan Johnson and a search for healthy longevity

NancyLebovitzJul 27, 2024, 3:28 PM

18 points

17 comments1 min readLW link

Adaptive Immune System Aging

johnswentworthMar 13, 2020, 3:47 AM

75 points

9 comments3 min readLW link

(Anti)Aging 101

George3d6Mar 12, 2025, 3:59 AM

5 points

2 comments3 min readLW link

(cerebralab.com)

Second-order selection against the immortal

MalmesburyDec 3, 2021, 5:01 AM

45 points

47 comments6 min readLW link

Age changes what you care about

DentinOct 16, 2022, 3:36 PM

141 points

37 comments2 min readLW link

Homeostasis and “Root Causes” in Aging

johnswentworthJan 5, 2020, 6:43 PM

86 points

25 comments3 min readLW link

[Question] Does anyone have an anki deck on ageing / rejuvenation biotechnology that they could share?

freedomandutilityOct 10, 2021, 4:54 PM

1 point

0 comments1 min readLW link

Immortality: A Practical Guide

G0W51Jan 26, 2015, 4:17 PM

53 points

62 comments36 min readLW link

Internet Literacy Atrophy

ElizabethDec 26, 2021, 12:30 PM

111 points

49 comments3 min readLW link

(acesounderglass.com)

Prediction market: Will John Wentworth’s Gears of Aging series hold up in 2033?

tailcalledFeb 25, 2023, 8:15 PM

15 points

4 comments1 min readLW link

(manifold.markets)

Highlights of Comparative and Evolutionary Aging

johnswentworthMay 22, 2020, 5:01 PM

56 points

10 comments2 min readLW link

Wormy the Worm

River LewisMay 21, 2022, 3:34 PM

3 points

23 comments5 min readLW link

(heytraveler.substack.com)

Nightclubs in Heaven?

J BostockNov 5, 2021, 11:28 PM

10 points

3 comments2 min readLW link

SENS and Givewell: Conversation between Holden Karnofsky and Aubrey de Grey

curiousepicMar 5, 2013, 7:24 PM

30 points

12 comments12 min readLW link

The Lens, Progerias and Polycausality

johnswentworthMar 8, 2020, 5:53 PM

71 points

8 comments3 min readLW link

[Question] Why is loss of muscle cells not considered one of the hallmarks of aging?

ChristianKlJan 5, 2021, 2:19 PM

11 points

9 comments1 min readLW link

Project Proposal: Gears of Aging

johnswentworthMay 9, 2020, 6:47 PM

58 points

43 comments7 min readLW link

Hypothesis: lab mice have more active transposons then wild mice

ChristianKlJun 5, 2021, 12:36 PM

20 points

14 comments1 min readLW link

How much should we value life?

Adam ZernerSep 6, 2021, 10:30 PM

30 points

25 comments38 min readLW link

Wrinkles

johnswentworthNov 19, 2019, 10:59 PM

81 points

14 comments4 min readLW link

Three Open Problems in Aging

johnswentworthNov 7, 2020, 7:39 PM

48 points

8 comments5 min readLW link

Here’s Why Indefinite Life Extension Will Never Work, Even Though it Does.

HomingHamsterJun 4, 2024, 6:48 PM

−13 points

5 comments18 min readLW link

Naked mole-rats: A case study in biological weirdness

eukaryoteMay 19, 2019, 6:40 PM

95 points

14 comments3 min readLW link

(eukaryotewritesblog.com)

Impact of aging research besides LEV

emanuele ascaniJun 6, 2019, 10:42 AM

15 points

0 comments7 min readLW link

Aging: A Surprisingly Tractable Problem

QuinnApr 8, 2021, 7:25 PM

11 points

0 comments1 min readLW link

Aldix and the Book of Life

villeJan 1, 2024, 5:23 PM

1 point

0 comments4 min readLW link

(medium.com)

Do not miss the cutoff for immortality! There is a probability that you will live forever as an immortal superintelligent being and you can increase your odds by convincing others to make achieving the technological singularity as quickly and safely as possible the collective goal/project of all of humanity, Similar to “Fable of the Dragon-Tyrant.”

Oliver--KlozoffJun 29, 2023, 3:45 AM

1 point

0 comments28 min readLW link

Beyond Biomarkers: Understanding Multiscale Causality

Matěj NekoranecJul 7, 2024, 9:56 AM

13 points

0 comments7 min readLW link

Lifeism in the midst of death

TobyBartelsDec 9, 2012, 1:28 PM

97 points

19 comments4 min readLW link

(DIY) FMT for Anti-Aging & Biohacking

EternallyBlissfulNov 28, 2022, 3:49 PM

26 points

7 comments6 min readLW link

Human performance, psychometry, and baseball statistics

Craig_HeldrethOct 15, 2010, 1:13 PM

33 points

21 comments6 min readLW link

Longevity interventions when young

George3d6Jul 24, 2020, 11:25 AM

45 points

17 comments39 min readLW link

(cerebralab.com)

[LINK] Larry = Harry sans magic? Google vs. Death

ShmiSep 18, 2013, 4:49 PM

36 points

55 comments1 min readLW link

The Fountain of Health: a First Principles Guide to Rejuvenation

PhilJacksonJan 7, 2023, 6:34 PM

115 points

39 comments41 min readLW link

BHTV: de Grey and Yudkowsky

Eliezer YudkowskyDec 13, 2008, 3:28 PM

10 points

12 comments1 min readLW link

Does Age Bring Wisdom?

Scott AlexanderNov 8, 2017, 7:20 AM

37 points

9 comments4 min readLW link

(slatestarcodex.com)

[Question] Why rationalists are not much concerned about mortality?

SurvivalBiasFeb 10, 2022, 12:11 AM

18 points

92 comments1 min readLW link

Many life-saving drugs fail for lack of funding. But there’s a solution: desperate rich people

MvolzMar 12, 2025, 3:24 PM

17 points

0 comments1 min readLW link

(www.theguardian.com)

An alarming fact about the anti-aging community

diegocaleiroFeb 16, 2015, 5:49 PM

44 points

65 comments2 min readLW link

Book review: Age Later

PeterMcCluskeyOct 27, 2020, 4:21 AM

28 points

3 comments4 min readLW link

(www.bayesianinvestor.com)

“The Singularity Is Nearer” by Ray Kurzweil—Review

LavenderJul 8, 2024, 9:32 PM

22 points

0 comments4 min readLW link

Introducing the Longevity Research Institute

sarahconstantinDec 14, 2018, 8:20 PM

79 points

11 comments1 min readLW link

(srconstantin.wordpress.com)

[Question] What to make of Aubrey de Grey’s prediction?

Rafael HarthFeb 28, 2020, 7:25 PM

23 points

18 comments1 min readLW link

Introducing the Longevity Research Institute

sarahconstantinMay 8, 2018, 3:30 AM

54 points

20 comments1 min readLW link

(srconstantin.wordpress.com)

Living Forever is Hard, or, The Gompertz Curve

gwernMay 17, 2011, 9:08 PM

67 points

87 comments3 min readLW link

Why people want to die

PhilGoetzAug 24, 2015, 8:13 PM

94 points

174 comments2 min readLW link

Being a donor for Fecal Microbiota Transplants (FMT): Do good & earn easy money (up to 180k/y)

EternallyBlissfulJul 8, 2022, 6:17 AM

36 points

26 comments8 min readLW link

(forum.effectivealtruism.org)

[linkpost] Project Blueprint: ‘Measuring and then maximally reversing the quantified biological age of my organs’

matteodimaioNov 16, 2021, 2:48 AM

2 points

0 comments1 min readLW link

Are healthy choices effective for improving live expectancy anymore?

Christopher KingMay 8, 2023, 9:25 PM

4 points

4 comments1 min readLW link

If calorie restriction works in humans, should we have observed it already?

Mark_EichenlaubApr 24, 2012, 4:28 AM

32 points

33 comments1 min readLW link

No comments.