What about the enhancement of human intelligence that was discussed here? (For example How to make superkids—LessWrong).
They probably have more than a 1% chance of success and could accelerate anti-aging research. Even if you consider the current research situation critically stalled.
I think this is true only in a part of contexts. If we are talking about AI alignment—probably skilled mathematicians or AI researches can be very fit. At least in the directions like interpretability. And this doesn’t necessarily correlate with their desires to do societally unconventional work. Why isn’t that so?