The next tractable useful milestone for LLMs, which is currently likely impossible for them, but plays to their strengths, might be room temperature superconductors.
Much like NS we know the physics and don’t necessarily need fundamental new insights, but finding the needle in the haystack that exhibits the properties we want is exceedingly hard.
Unlike NS though it can’t be solved purely theoretically—at best it can generate likely candidates which we’d then have to build and test in the real world.
I find these debates sort of weird in the present timeline. 5 years ago they were relevant, when people said—we wouldn’t hook up a superintelligent AI to the internet, whereas now we simply give them the credentials to all our accounts and let them rip. Even a very clever human could obviously do tremendous harm in that situation.