Flowers are selective about what kind of pollinator they attract. Diurnal flowers use diverse colours to stand out in a competition against their neighbours for visual salience. But flowers with nocturnal anthesis are generally white, as they aim only to outshine the night.
O mysterious temple of chance, for what did the scattered parts of your whole link arms to shape you? And the mysterious ceasefire they declared to heed you? O quiescent eye of a hurricane, what holds you together? O molecular weave of water and sunlight, why even bother?
Edit: I found the post usefwl, thankmuch!!
Mh, was gonna ask when you were taking it. I’m preparing to try it as a sleep-aid for when I adjust my polyphasic sleep-schedule (wanting to go fm 16h-cycles potentially down to 9h) bc it seems potentially drowsymaking and has much faster plasma decay-rate[1] compared to alts. This is good for polyphasic if not want drowsy aft wake.
The data in [1] concerns 100mg tablets, however, and a larger dose (eg 400mg) may be longer. The kinetic model[2] they use will prob be good estimate of plasma concentrations even if adjust dose.
Questions is whether it’s good estimation for duration of action in the brain, esp given that it’s “single-compartment model” (the blood is one compartment, and the brain is another). My heuristic for whether plasma T predicts brain T is whether the molecule v easily passes the BBB (as melatonin does), since then I can guess that the curve for the brain will look similar to the curve for the blood, offset slightly down and to the right.
Hot tip, you can screenshot pdf equations (i rec Text Grab or Greenshot) and ask gpt-4-turbo (updated) to write it in latex and/or jupyter-notebook-compatible python[3].
Getting a tweakable python model for it was nontrivial after 35m of trying, so i’ll prob j wing it w 200mg 1h pre bedtime and do 3h sleep, and adjust bon feelings. ig the primary variable that determines how alert i feel upon waking up is getting the sleep-cycle timing right, and planning my wake-up routines (lights & text-to-speech-model as alarm) for j after I’ve done REM-sleep[4].
While I probably would feel alert if waking up in middle of REM-sleep (after emerging from deep), I want to avoid that bc studies show bad effects from targeted deprivation of REM (leaving other phases untouched).