I think I’d add: ask any medical doctor friend (or AI) to review the medication you take in a year. It can reveal bad habits like taking NSAID for bad reasons. Some people take them for any kind of pain and it can really flare up infections to a deadly point.
Not sure it fits in here but it came to my mind.
Also, I suspect the makers use some kind of water soluble molecule that contribute to its mechanical properties. This ensures that they are disposable because as soon as you wash them with water they lose a lot of their mechanics. I recommend making them last as long as you’re feeling comfortable without washing, then using friction from some cloth or tissue paper to wipe its surface instead of soaking it. When you finally wash them, cold water and no soap.
The most effective ones for me have always been the MOLDEX—Pura Fit 7700. They can be bought in bulk too.
Also, your username is quite fitting for this topic.
Sharing my setup too:
Personnaly I’m just self hosting a bunch of stuff:
litellm proxy, to connect to any llm provider
langfuse for observability
faster whisper server, the v3 turbo ctranslate2 versions takes 900mb of vram and are about 10 times faster than I speak
open-webui, as it’s connected to litellm and ollama, i avoid provider lock in and keep all my messages on my backend instead of having some at openai, some at anthropic, etc. Additionally it supports artifacts and a bunch of other nice features. It also allows me to craft my perfecr prompts. And to jailbreak when needed.
piper for now for tts but plan on switching to a selfhosted fish audio.
for extra privacy I have a bunch of ollama models too. Mistral Nemo seems to be quite capable. Otherwise a few llama3, qwen2 etc.
for embeddings either bge-m3 or some self hosted jina.ai models.
I made a bunch of scripts to pipe my microphone / speaker / clipboard / llms together for productivity. For example I press 4 times on shift, speak, then shift again, and voila what I said was turned into an anki flashcard.
As providers, I mostly rely on openrouter.ai which allows to swap between providers without issue. These last few months I’ve been using sonnet 3.5 but change as soon as there’s a new frontier model.
For interacting with codebases I use aider.
So at the end all my cost comes from API calls and none from subscriptions.
Very interesting of you to think of it that way. It turns out that it’s very in line with recent results from computation psychiatry. Basically in depression we can study and distinguish how much the lack of activity is due to “lack of ressource to act” vs “increased cost of action”. Both look clinically about the same but underlying biochemical pathways differ, so it’s a (IMHO) promising approach to shorten the times it takes for a doctor to find the appropriate treatment for a given patient.
If that’s something you already know I’m sorry, I’m short on time and wanted this to be out :)
Just a detail : Haven’t retinoids been discovered when looking for cancer treatments? I thought it was the origin story behind isotretinoin.
My personnal solution to this is to mostly use Anki for everything and anything.
It helps not loose my momentum: if I see my cards about the beginning of the articles about transformers it increases my chance of finishing the article
It garuantees that I never get the dreaded my knowledge is limited to a couple of related keywords ("self-attention", "encoder"/"decoder") with no real gears-level understanding of anything. feeling. Making it all the more easier to get back to reading.
In fact I hate the number 2 feeling so much that it was a huge motivation to really master Anki. (1300 day streak or so with no sign of regret whatsoever)
I think very cheap carabiners are extremely fragile especially for repeated use. I saw a failing mode where the mobile axis just opens in the wrong way by going around the stator. Keep that in kind when choosing which carabiner to use.
Might be better to keep using ring keyholders but have one decently strong carabineer to hold the rings together instead of what you did : tiny carabiners that hols onto a ring no?
I don’t really like any of those ideas. I think it’s really interesting that aware is so related though. I think the best bet would be based on software. So something like deepsoftware, nextsoftware, nextgenerationsoftware, enhancedsoftware, etc.
For ayone trying to keep up with AI for film making, I recommend the youtube channel curious refuge https://www.youtube.com/channel/UClnFtyUEaxQOCd1s5NKYGFA
Also, velcro comes in many strength and sizes. I find heavy duty velcros to be frequently underused in such DIY projects
DIYPerks on youtube did just that: https://www.youtube.com/watch?v=J2aY6cvk-WI
Medical student here, I get that a lot it’s called interference at least in the supermemo sphere.
My personnal solution to this is to add more cards. For example “is friendA born before or after friendB?”, “what are the birthday of friendA and friendB?”.
The latter question is a crucial example actually. It makes you practice the recall of the distinction between the interference instead of the raw recall of each datum.
Also, as other suggested here, mnemonics help a ton: for example is there an intuitive reason you can link to friendB having an odd birthday and friendA having an even birthday? If so, add a third anki card to never forget the mnemonics.
You also might be interested in the 20 rules of formulating knowledge by supermemo.
One insight I had over the years on anki is that because of the algorithm, having more cards is not penalizing.
Also I created AnnA—Anki Neuronal Appendix to help spread reviews with semantic similarity if that helps.
Based on?
The wikipedia page explicitely states that they don’t have the same binding profile and also Ockham’s razor as it seems unlikely that two different drugs with two different binding profile perform similarly on ADHD.
“stronger per weight impact on dopamine”? That’s not how drugs or biology work. Every neurotransmitter and hormone has several different receptors that different drugs affect in different ways.
I’m aware. I know my sentence did not sound professional but it was on purpose. I think it’s true nonetheless : using a more specific sentence would involve naming specific receptors and I don’t want to check each of them (MPH, ETH, modafinil). Being specific here doesn’t really matter because I’m expressing surprise as to your apparent certainty. Your certainty indicates that you researched those specifics, hence what I was asking.
Regarding the study you linked, I don’t find anything relevant to ETH’s effectiveness compared to MPH on ADHD.
To clarify because I think I sound rash when really I’m not:
I’m surprised you seem to have low uncertainty on ETH being more effective than MPH on ADHD, even though ETH has never been studied on ADHD, never been compared to MPH, possibly never even been studied on humans (?).
It is certain that ETH and MPH don’t have the same binding profile. I would be extremely surprised if they didn’t have a difference in effectiveness in treating ADHD if compared in a head to head RCT. But I don’t really have an opinion on which would be better. You seem to do so I’m probably lacking information about some neurotransmitters and ADHD.
PS: actually I do think ETH would perform worse than MPH. But probably not by a large margin. ETH could also be more pleasurable but less tolerable. All of this with very low certainty.
Sure!
To me the only relevant passage seems to be this one:
Ethylphenidate is more selective to the dopamine transporter (DAT) than methylphenidate, having approximately the same efficacy as the parent compound,[6] but has significantly less activity on the norepinephrine transporter (NET).[8] Its dopaminergic pharmacodynamic profile is nearly identical to methylphenidate, and is primarily responsible for its euphoric and reinforcing effects.
You said:
methylphenidate is obligatory for some kids while ethylphenidate is illegal, and they’re basically the same but ethylphenidate is probably slightly better.
I disagree with “they’re basically the same”. I mean of course they are more similar together than compared to acetaminophen but I do think that they would probably be different in terms of effect on ADHD or hedonic perception if compared head to head.
I don’t see how ethylphenidate would be better. Is it “better in terms of how pleasurable it is”? As in recreationnal use. Because then there’s no point in comparing to methylphenidate beging given to kids. And if it’s in terms of how good it treats ADHD then I don’t know where it’s coming from. Is that because it has a stronger per weight impact on dopamine than on norepinephrin? IIRC modafinil has way more of an impact on dopamine than norepinephrine but helps poorly for ADHD.
I really must be missing something. Thank you for helping me out!
Also:
All available data on ethylphenidate’s pharmacodynamics are drawn from studies conducted on rodents.
For the curious, famous researcher David Nutt is working on alcohol replacements too. He’s part of Alcarelle, now called gaba labs and IIRC they bet on benzodiazepine derivatives.
for example, methylphenidate is obligatory for some kids while ethylphenidate is illegal, and they’re basically the same but ethylphenidate is probably slightly better.
This sounds surprising to me. Can you elaborate on the source and thought process leading you to this?
I use anki flashcard for everything
There’s a great youtuber called the thought emporium who did genetic engineering on himself. I highly recommend checking them out :
https://www.youtube.com/watch?v=J3FcbFqSoQY
And the 2year follow up: https://www.youtube.com/watch?v=aoczYXJeMY4
The tldr is he created a virus then ate it to make his digestive system have more of the gene that makes lactase as he was very intolerant. 2 years later the effects are starting to wear off as cells get replaced but it seems to have had a very high ROI
I can attest to the usefulness of infrared cameras.
I didn’t want to rely on “do I have a usb-c phone in 15 years” so opted for a handheld model called “Mastfui FY12″.
Very happy with it. I was able to figure out many things about the insulation of the building I live in. Many coldspots easy to fix. So I’m now lending it to all my friends to help them reduce the wasted heat in their home.