To me the only relevant passage seems to be this one:
Ethylphenidate is more selective to the dopamine transporter (DAT) than methylphenidate, having approximately the same efficacy as the parent compound,[6] but has significantly less activity on the norepinephrine transporter (NET).[8] Its dopaminergic pharmacodynamic profile is nearly identical to methylphenidate, and is primarily responsible for its euphoric and reinforcing effects.
You said:
methylphenidate is obligatory for some kids while ethylphenidate is illegal, and they’re basically the same but ethylphenidate is probably slightly better.
I disagree with “they’re basically the same”. I mean of course they are more similar together than compared to acetaminophen but I do think that they would probably be different in terms of effect on ADHD or hedonic perception if compared head to head.
I don’t see how ethylphenidate would be better. Is it “better in terms of how pleasurable it is”? As in recreationnal use. Because then there’s no point in comparing to methylphenidate beging given to kids. And if it’s in terms of how good it treats ADHD then I don’t know where it’s coming from. Is that because it has a stronger per weight impact on dopamine than on norepinephrin? IIRC modafinil has way more of an impact on dopamine than norepinephrine but helps poorly for ADHD.
I really must be missing something. Thank you for helping me out!
Also:
All available data on ethylphenidate’s pharmacodynamics are drawn from studies conducted on rodents.
I do think that they would probably be different in terms of effect on ADHD or hedonic perception
Based on?
And if it’s in terms of how good it treats ADHD
That’s what I meant.
Is that because it has a stronger per weight impact on dopamine than on norepinephrin? IIRC modafinil has way more of an impact on dopamine than norepinephrine but helps poorly for ADHD.
“stronger per weight impact on dopamine”? That’s not how drugs or biology work. Every neurotransmitter and hormone has several different receptors that different drugs affect in different ways.
As for reasons you might expect it to be better, you can see this but I suspect I won’t be able to explain my actual reasoning to you in an expeditious way.
The wikipedia page explicitely states that they don’t have the same binding profile and also Ockham’s razor as it seems unlikely that two different drugs with two different binding profile perform similarly on ADHD.
“stronger per weight impact on dopamine”? That’s not how drugs or biology work. Every neurotransmitter and hormone has several different receptors that different drugs affect in different ways.
I’m aware. I know my sentence did not sound professional but it was on purpose. I think it’s true nonetheless : using a more specific sentence would involve naming specific receptors and I don’t want to check each of them (MPH, ETH, modafinil). Being specific here doesn’t really matter because I’m expressing surprise as to your apparent certainty. Your certainty indicates that you researched those specifics, hence what I was asking.
Regarding the study you linked, I don’t find anything relevant to ETH’s effectiveness compared to MPH on ADHD.
To clarify because I think I sound rash when really I’m not:
I’m surprised you seem to have low uncertainty on ETH being more effective than MPH on ADHD, even though ETH has never been studied on ADHD, never been compared to MPH, possibly never even been studied on humans (?).
It is certain that ETH and MPH don’t have the same binding profile. I would be extremely surprised if they didn’t have a difference in effectiveness in treating ADHD if compared in a head to head RCT. But I don’t really have an opinion on which would be better. You seem to do so I’m probably lacking information about some neurotransmitters and ADHD.
PS: actually I do think ETH would perform worse than MPH. But probably not by a large margin. ETH could also be more pleasurable but less tolerable. All of this with very low certainty.
Sure!
To me the only relevant passage seems to be this one:
You said:
I disagree with “they’re basically the same”. I mean of course they are more similar together than compared to acetaminophen but I do think that they would probably be different in terms of effect on ADHD or hedonic perception if compared head to head.
I don’t see how ethylphenidate would be better. Is it “better in terms of how pleasurable it is”? As in recreationnal use. Because then there’s no point in comparing to methylphenidate beging given to kids. And if it’s in terms of how good it treats ADHD then I don’t know where it’s coming from. Is that because it has a stronger per weight impact on dopamine than on norepinephrin? IIRC modafinil has way more of an impact on dopamine than norepinephrine but helps poorly for ADHD.
I really must be missing something. Thank you for helping me out!
Also:
Based on?
That’s what I meant.
“stronger per weight impact on dopamine”? That’s not how drugs or biology work. Every neurotransmitter and hormone has several different receptors that different drugs affect in different ways.
As for reasons you might expect it to be better, you can see this but I suspect I won’t be able to explain my actual reasoning to you in an expeditious way.
The wikipedia page explicitely states that they don’t have the same binding profile and also Ockham’s razor as it seems unlikely that two different drugs with two different binding profile perform similarly on ADHD.
I’m aware. I know my sentence did not sound professional but it was on purpose. I think it’s true nonetheless : using a more specific sentence would involve naming specific receptors and I don’t want to check each of them (MPH, ETH, modafinil). Being specific here doesn’t really matter because I’m expressing surprise as to your apparent certainty. Your certainty indicates that you researched those specifics, hence what I was asking.
Regarding the study you linked, I don’t find anything relevant to ETH’s effectiveness compared to MPH on ADHD.
To clarify because I think I sound rash when really I’m not:
I’m surprised you seem to have low uncertainty on ETH being more effective than MPH on ADHD, even though ETH has never been studied on ADHD, never been compared to MPH, possibly never even been studied on humans (?).
It is certain that ETH and MPH don’t have the same binding profile. I would be extremely surprised if they didn’t have a difference in effectiveness in treating ADHD if compared in a head to head RCT. But I don’t really have an opinion on which would be better. You seem to do so I’m probably lacking information about some neurotransmitters and ADHD.
PS: actually I do think ETH would perform worse than MPH. But probably not by a large margin. ETH could also be more pleasurable but less tolerable. All of this with very low certainty.