[I have not read your post in detail; I read up until “Filling in gaps with learning creates the capabilities expropriation pipeline” and skimmed the rest. Apologies if this leads to some central misunderstandings, I’ve tried to check for those but may have missed some]
[caveat, I am not a neuroscientist]
My main-line expectation for PBE/WBE development in the short-term routes through
performant non-invasive neuronal imaging at high enough spatial / temporal resolutions to capture relevant structure for reconstructing human behavior(s),
collecting a large amount of brain data in this modality and reaping the benefits of scale by training a foundation model with a reconstruction objective on such a dataset,
[some ML algorithmic advances that allow the PBE/WBE to express a human learning algorithm in silico]
I expect the PBEs made by hill-climbing with this research agenda to look like “t-humans” where “snapshots” are created that emulate human behavior over “t” seconds, and e.g. you could generate some artifacts like approximate HCH with this method.
I’d like to make a few claims:
these PBEs will be alien by default because single-neuron imaging is hard & you can only approximate single-neuron resolution. (One way to do this is using transcranial ultrasound + a blood contrast agent to image brain vasculature as a corollary of firing patterns. A very rough estimate is that this gets you ~3mm^3 voxel imaging at ~5Hz?).
this PBE/WBE training trajectory suffers from many (if not all) of the issues you presented in your post
connectomics-based WBE methods, on the other hand, might not? (here I’m using “connectomics” as a stand-in for any data-collection mechanism that has e.g. single-neuron resolution). Or at least they’re more hopeworthy than the vibe I get from reading this post
Expanding on this:
clearest risk I see from this is reconstructing cortical learning algorithm(s), you could get similar results from distilling from PBEs trained in the previous way
mechanistic understandings of e.g. Steering Subsystem seems potentially much more differentially useful for alignment
modularity means a research effort could maybe specialize in iterating on data collection methods in non-intelligence-juice relevant portions of the brain (???)
smth smth threshold effect where if you just have all the data at a high enough resolution to capture all the structure you have a WBE by default?
Also I generally expect it to be somewhat difficult to distill insights from the brain with either of these methods. More the foundation model esque approach than the “image all the neurons in a bunch of detail and reconstruct local interactions & get accurate global models as a result”
Non-invasive ultrasound + contrast (e.g. microbubbles) can reconstruct vasculature throughout the cranium. Merge is also working on tooling to increase the fidelity of ultrasound-based methods (see Mikhail Shapiro’s past research (cofounder of Merge) on e.g. gene therapies for acoustic phosphorescence) that would potentially provide single-neuron level resolution throughout the brain as well.
(There are also some other modalities people are exploring, but these are just the ones I’ve heard the most about that can image deeply)