Not the half life active curve, but people underrate how the curve for decreasing your tolerance as you abstain differes between substances. There isn’t much research into 1. how a substance becomes less effective over time nor 2. How fast you become addicted.
I assume this is 1 reason a lot of people got addicted to nicotine: despite the shorter half life you need a longer time off to reset the effectiveness. Caffiene after 2-7 days your body starts to undo its chemical adaptations and mostly washed out after a few weeks. For nicotine it’s closer to a week to start 12 weeks to wash out an addiction.
From Largely Vibes
Adderall: Proscribed for every day, Scott Alexander recommends 5 days on 2 off
Nicotine: once every week? (Alexey Guzey started planning with once every third day, in 2024 self described as a smoker, but smoking what?). Problem one: since half life is only 2h to be stimulated all day you’d ingest several times likely training yourself to reach for it when tired unless you’re counting.
Caffeine: every other day likely keeps the same effect size?
Modafinil: folk wisdom is once per week else it stops working. This is “taking every day will really reduce effects after 90-180 days”, unclear if this means it’ll be effective over 5 years.
Alchohol: 14 drinks per week for men or 8 for women makes you an alcoholic and will probably cause an addiction over several years, sooner if higher. But the effect size doesn’t change as much. Compare how “holding your liquor” means tolerating maybe 50% more for your weigh, not nicotines pack a day vs 1 cig for irregular smoker or several cups of coffee being 500mg to not have the effect of 100mg did initially.
I’d be curious if anyone has actually looked into for Nootropics
What range of dosing schedule maximizes long term usefulness
What dosing schedule is dangerous and indicates big problems within the next month
Depends on your model of addiction: is it pavlovian conditioning to generate the idea to smoke or a biochemical change which generates cravings you sooth by smoking? The later latter on, the earlier probably some part of causing smoking more.
All the +400mg/day people I know take it every day. Though I wouldn’t notice 200
Probable “write down your exact dowing schedule and if you feel a craving for more abstain for a long while” works, but how strong a craving do you get? (And doesn’t address reduced efficacy)