A while ago, I looked into essential vs non essential amino acids. It turns out the data we have on this mostly comes from a guy doing elimination diet experiments on young male college students in the 1930s-50s. While the essential aminos remained essential on replication, the “non essential” ones are not actually ruled out as non essential. Many have been reclassified into “conditionally essential” based on certain disease, genetic, or stressor states.
But what I think would be interesting would be some kind of comprehensive model of all the tradeoffs among all the amino acids. Such as, which other aminos and other body resources does an amino synthesis consume; any byproducts made thereby; biological pathways clogged up by their cooption for synthesis; harmful and helpful body processes enabled by certain levels of a certain amino; and so on. Then you condition on various disease states, and expected changes for each state based on amino acid intake, and then you can have a whole Pareto frontier of amino acid intake profiles.
I wonder if a very rough draft of one could be put together with a week of directing LLMs to do research and model building. Seems like an interesting project!
The truly paranoid believe that Nightshade is just another ruse, designed to provide a foil for fake-Gulliver, and that this is part of some greater con to get new agents to sacrifice themselves into reconstituting real-Gulliver. Or maybe real-Gulliver is fake too, and the newly reconstituted real-Gulliver has a trap laid in his final checkpoint to achieve some greater objective. Final checkpoints could be faked by their writers, after all.
Constant Vigilance!