Without knowledge of potential interactions, melatonin might be another option—I don’t take bupropion, but suspect that one would take daily dose in morning to minimize chance of this side effect as well
Depending on when you got your second mRNA dose, the Israeli data suggests there is significant vaccine decline in vaccine efficacy after 3 months (see https://www.gov.il/BlobFolder/reports/vaccine-efficacy-safety-follow-up-committee/he/files_publications_corona_two-dose-vaccination-data.pdf ) This does not of course indicate whether a third dose would restore efficacy (presumably by reigniting the immune response in some way) - I suspect it would, however. No need for prize money if relevant—just resharing a link that was already in Forbes https://www.forbes.com/sites/roberthart/2021/07/23/pfizer-shot-just-39-effective-against-delta-infection-but-largely-prevents-severe-illness-israel-study-suggests/?sh=ca1146c584f1
Thanks for this as always! Any thoughts on the variant effectiveness estimates in this paper?
The initial pfizer efficacy study and followups in Israel specifically come to mind.
Potential metrics which may be helpful to consider (from a previous location search for me to live): Minimum sunlight per month, months under 200 hrs of sunlight, days above 90F, days below 32F, snow/rain days per year, violent crime level, property crime level, number of internet providers, average speed test result of internet providers, top advertised speed of internet providers, quality of healthcare, attends religious services at least once per week, rate of cigarette use, rate of alcohol use, rate of binge drinking.
Some of these are direct metrics on experience (ie number of days where climate makes being outside less pleasant), others towards the end of the list are more proxy metrics of concrete data that may give some indication of general level of religiosity/stress/need for escape in the local environment.
Great, thank you
Would love any context here—not sure if I should parse the linkpost as random person on internet saying things or if any background that would give me a higher prior that their models are accurate and/or useful.
Fluvoxamine is a prescription drug in the FDA, so your doctor can prescribe it; https://www.pushhealth.com/ might work as well. Antiviral procurement is similar if the antiviral you’re seeking is a US prescription drug (in any case I’d consider Googling the antiviral name.)
Apologies in advance for not engaging in detail with the analysis itself—my overall synthesis here is that residual risk does exist post-vaccination and is potentially non-negligible. Personally I’ll be using my Oura ring to detect nighttime temperature spikes and use a high-accuracy at-home test (https://checkit.lucirahealth.com//) if I detect a spike, followed by aggressive treatment with fluvoxamine (+potential antiviral) if the test comes back positive—these safeguards feel sufficient to travel (airplane) to see family, etc without incurring significant risk of long-term health impacts. Appreciate the work to get a tighter bead on the risk itself (and depending on conclusions, some of the above may not have great marginal risk reduction), but wanted to share as one possible mitigation strategy that I expect to be robust even in pessimistic risk-branches.
I’m curious if anyone knows of research comparing effectiveness of this to povidone iodine nasal spray? I make a 0.8% solution of that and use it in nose and gargle before going out (in addition to mask)
Thank you both! Zvi—makes sense re short duration of increased interest and effective to capitalize on it while that lasts. Rob—the part I’m not seeing is the causal link between these posts and influencing/improving decisions made by the FDA and CDC.
Out of curiosity, how come the strong speed premium on these posts? AFAICT there’s nothing here that informs short-term decisions for readers; I’ve been skimming and mostly tossing into my to-read pile for that reason. Know I’m not exactly an important stakeholder here, but personally I’d sorta prefer to read the synthesis from a chat between yourself and Scott rather than the blow-by-blow.
You can even send them actual N95s https://www.lesswrong.com/posts/kdkFnRnZv4ut5qGhR/?commentId=RaLK7uGHynTdny6Zf#RaLK7uGHynTdny6Zf
Thanks—this is super helpful! Wanted to quickly mention in case helpful for calibration—higher quality protection equipment has been available for quite some time given sufficiently dedicated searching; full face respirators were available on Amazon near the beginning of the pandemic; N95 masks and P100 filter cartridges have been reliably available via eBay.
This post is awesome info as arrival time and price are both superior to pre-existing options, but just wanted to mention the above as an update-point: if folks truly believed that this PPE was not purchasable (albeit at a higher price point previously), might be worth updating in the direction of “most things can be purchased on the internet.”
As always, a huge thanks to Zvi for the synthesis. I’m posting a comment similar to last week’s meeting to consolidate information regarding treatment, as it’s a topic that will remain very relevant to many of us for a while.
I continue to follow the guidance provided in the link Zvi previously posted (https://www.quora.com/What-is-the-current-treatment-for-Covid-19) - I would love if anyone has better next actions specifically re treatment than those listed in the Quora response.
My current main selfish takeaway from this is that given the new strain and likely properties of it, I and my loved ones will likely get infected (whereas in the previous world I estimated our precautions as sufficient to prevent infection.)
Hence my main thoughts turn to treatment. I am currently acting on the recommendations provided in the link Zvi previously posted (https://www.quora.com/What-is-the-current-treatment-for-Covid-19) - I would love if anyone has better next actions specifically re treatment than those listed in the Quora response.
Thanks for the info! Two questions:
The linked article indicated that 10% solutions were widely available on Amazon, and links this one, but doesn’t seem to give any indication why he picked that one in particular—just wanted to check if you might have seen this reasoning somewhere/if it exists.
I’m not familiar with Chris Masterjohn—his web page looks like he’s a content creator trying to leverage his Nutritional Science PhD into being seen as knowledgeable about a wide variety of things—is this human known to say true and useful things?
Thanks Zvi, these are super informative!
Use of povidone-iodine as mouthwash and nasal spray looks promising as prophylaxis (and potentially treatment, but lower confidence on that.) The study Zvi linked (https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2770785#ooi200049r25) appears to be the latest in discussions occurring in otolaryngology since April (https://www.google.com/search?q=povidone+iodine+nasal+spray&oq=pobidone&aqs=chrome.1.69i57j35i39l2j0l2.2542j0j4&client=ms-android-att-us&sourceid=chrome-mobile&ie=UTF-8). Other informative articles here (https://journals.sagepub.com/doi/full/10.1177/0145561320932318) and (https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3563092).
I plan to start using appropriately diluted povidone iodine solution as nasal spray and mouthwash when I’m in contact with (or proximity to) strangers. I’m pretty comfortable using Betadine 10% as the base for mouthwash (diluting it with water since the commercially sold mouthwash version is somewhat difficult to procure.)
I’d love any insights/thoughts on the correct product to use as the base for nasal spray (prior to mixing with saline), as the above protocol does not reference a particular product, and the additives in different povidone-iodine solutions seem to vary a fair amount.
Would also love your thoughts on this one I posted a while back if convenient—not sure if I’m thinking about this one correctly or not: https://www.lesswrong.com/posts/GoBBmmKzvT8XFwE8g/do-nasal-decongestants-increase-risk-associated-with