Pretty obvious, but: when applying the Chesterton’s Fence principle to decide whether or not to remove the metaphorical fence, consider two things:
Remember that the existence of the fence itself has a cost. If it’s an object, it’s cluttering up space and might demand repair / organization. If it’s a rule, it’s demanding attention and detracts from other rules. Etc...
Removing the fence will likely remind you what it was for when eventually something breaks. Value of information!
How do you think “Immunity via Entanglement” intersects with Buddhism?