Slightly known unknowns

Inspired by What visionary project would you fund?, I’m wondering about whether there are known blank areas in our knowledge which might turn up surprising knowledge.

Once upon a time, the sun was a mystery. People had a pretty good idea of its mass, and how much chemical energy would be needed to keep it shining. I don’t remember how long the sun could last running on chemical energy, but it didn’t seem plausible that it could be so new.

It turned out that chemical energy wasn’t the only possibility.

I don’t get the impression that there was wide appreciation that most of the world was being ignored by scientists because the calculations were too difficult—until the calculations were made easier.

Do people here expect to be surprised by whatever it takes to understand qualia?