From my notes for the book 0 to 1: “Competition is destructive and not a sign of value”.
For your alpha, look for secrets (things you know or are confident in, but no one else is). Create something that is 10x better than any alternative. Don’t start the next restaurant. You want to be the next monopoly.
Not the focus of that book, but personally, I would also like to create value, not only capture it. So I’d aim not to start the next Elsevier, Coca-Cola, or Facebook, even though they have great profit margins. There are good and bad monopolies.
Molecular dynamics was also the first counterexample I was thinking of.
Using heuristics here get’s easier though if you require less precision. I actually think that textbook could totally be written. Maybe not for why it is −98 rather than −96, but different heuristics and knowing the boiling points of other molecules should get you quite far (Maybe why it is −98 rather than −108). I would absolutely read that textbook.