The current tests are looking for the presence of a specific virus—looking at the genome using RT-PCR technology so the answer is no. (eek at being so definite)
PCR (polymerase chain reaction) is a DNA amplification technique
but Coronavirus is RNA so reverse-transcriptase (RT) is used to make a DNA ‘template’ from the RNA.
Some info. from Cambridge and Glasgow Universities regarding Covid-19 Genomics UK Consortium—A project to map how COVID-19 spreads and behaves by using whole genome sequencing will show if the virus is mutating.
Consider the demographics of the populations. Age, concurrent disease, levels of smoking, air pollution etc…
Levels of testing/recording/reporting....
(hope this makes some sense—written in a rush)
Some first thoughts:
It only takes one person to infect you.
You can reduce your contact, but what about your contacts contacts?
How many people is the person serving in the grocery store coming into contact with?
How strict are they all with their precautions?
What about other members of the same household and all their contacts?
The recommended distance between people may not be sufficient to prevent transmission.
It’s easy to break the distance rule (might just be a second or two even if being v. careful).
Fomite transmission (inanimate carrier of infectious diseases)
Pre-(noticed) symptomatic transmissions. What if someone has a fever during the night, how many people would notice it/associate it with COVID? (It always amazes me the denial some people can have about their symptoms.)
QUESTION - has anyone come across data about duration of a COVID-fever? (although there’s a massive potential for variability between individuals so not sure the data would actually be useful/representative/meaningful but it’d be good to have whatever information is out there...)
virus is attacking the ACE2 molecules.
This is very interesting information. I was wondering (but not enough to actually research it) why diabetes mellitus (DM) was a bigger risk factor of severe disease than I would have associated with the “normal” increased risk with infections in patients with DM.
A quick search led me to this article in the Lancet.
The expression of ACE2 is substantially increased in patients with type 1 or type 2 diabetes, who are treated with ACE inhibitors and angiotensin II type-I receptor blockers (ARBs).
Hypertension is also treated with ACE inhibitors and ARBs, which results in an upregulation of ACE2.
ACE2 can also be increased by thiazolidinediones and ibuprofen.
(has a) functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2 (COVID-19 virus)
yellow fever vaccine is one that springs to mind that also uses eggs in production
The yellow fever vaccine is made by growing yellow fever virus in mouse embryo cells and in chick embryo cells. The final preparation of the vaccine is made in eggs. Growing yellow fever virus in mouse and chick cells over and over again weakened it. Therefore, when this “live, weakened” virus is injected, a protective immune response develops without causing illness. SOURCE
THIS IS FOR GENERAL INFORMATION ONLY.
I am in no way saying this relates to COVID19 but to give an example of a virus that can spread a long distance ‘in the wind’.
“foot and mouth disease” caused by a picornavirus affects cattle, pigs, sheep, goats (+ other cloven-footed animals).
… Virus was reported to travel over water >250 km (155 miles) from Brittany, France, to the Isle of Wight, UK, in 1981, but it usually travels no more than 10 km (~6 miles) over land. SOURCE
I’m happy to read stuff and critique. (I go harsh but hopefully fair).
General editing/formatting/readability appraisals.
I’ll be of most of use on bio-medical topics (although the discussions here about vaccine development are way above my knowledge base so I’d avoid that!)
Covid-19 Genomics UK Consortium - A project to map how COVID-19 spreads and behaves by using whole genome sequencing.
Some info. from Cambridge and Glasgow Universities (UK government/NHS many other UK universities involved too).
I’ve just stumbled across this press report:
A man has died and his wife is under critical care after the couple, both in their 60s, ingested chloroquine phosphate, an additive commonly used at aquariums to clean fish tanks. Within thirty minutes of ingestion, the couple experienced immediate effects requiring admittance to a nearby Banner Health hospital.
No mention of how much they ingested.
Chloroquine phosphate for fish-tanks, not human grade.
But a little knowledge without understanding can be a dangerous thing …
Some quick thoughts if anyone wants to do a dive:
The article is talking about “live” yoghurt i.e. cultured milk with no other additives.
The main bacteria to culture milk into yogurt are:
Lactobacillus bulgaricus (Lactobacillus delbrueckii subsp. bulgaricus) and Streptococcus thermophilus.
In what countries do people eat a lot of natural live yoghurt? (per capita not overall amounts). Bulgaria (a clue in the name of the first bacterium) Russia? Greece? Spring to mind. Local knowledge would help here.
What are the demographics of those populations? (total population, % of old folks most likely to suffer severe disease)
What’s the COVID19 situation in these places?
The link says:
The cytokine storm is induced by the virus and the bacteria acting together.
I would want to see some evidence for this statement for instance levels of secondary infections being tested/confirmed/reported. (and the use of antibiotics as prophylactic or therapeutic agents - could antibiotics making things worse in some cases by killing of the good bacteria too????
This image looks like a good guide of when to seek medical attention for a fever:
Do you know how to use a gun?
Where would you store it? Easy access to loaded gun or locked in a safe /unloaded.
Would you be willing to use a gun? (waving one round for home invader to disarm you and then have it pointed back at you—if they’re not already armed.)
What risk factors are in your house (i.e. children) that having a gun might be more of a threat to household than invaders?
What kind of distance would be be defending yourself from? small apartment v. taking out intruder from the top of the stairs out of arms reach.
A lot of other things can be used for defence. Something I read as a kid with plenty of suggestions was the SAS survival handbook. A kettle cord with a plug on the end (UK 3 point plug) was one that stuck in my mind (but these days a phone charger might be the easiest thing to hand) and I remember being on a regularly hijacked bus route with my can of deodorant ready to be sprayed in someone’s face.
Do you have anything really worth defending in a robbery? (violent attackers a different matter).
get a pulse oximeter I think is the original comment.
Included on the justified advice thread.
A discussion on the what to do when infected thread was the prompt yesterday, (I’m not skilled enough to be able to link to the comment directly).
posted a comment instead of reply. please delete
It’s a bit of a peeve of mine this down voting without explanation, but I’m getting used to it! I up-voted yesterday :)
blood oxygen—Hb/O2 dissociation curve.
Edited to add: It probably wouldn’t bother me so much if it wasn’t giving out negative “karma”—that’s not something I’d dole out to anyone. Or if it didn’t just take one vote (not everyone here is always as rational as they’d like to think) to remove comments from general view.
Gargling with salt water is a traditional method of treating sore throat/tonsillitis/swollen sub-mandibular lymph nodes.
I’m getting a little obsessed with garlic so I’d gargle with a garlic solution after the salt...
I’m not sure this has been mentioned so, if you’ve got a thermometer …
Get to know your normal temperature.
Take it when you get up, middle of the day and before bed. (clean with alcohol after each use) Nice chance to make a graph.
There’s daily fluctuations in temperatures and method of taking it influences the readings so stay consistent. (rectal most accurate method but might be the least popular site—especially if sharing equipment!)
My normal sublingual temperature is 36.6 C
If you know what’s normal for you then you’ll know if it’s increased.
Having been in isolation for the last 10 days with a possible covid19 case (gut says no, head says hope so because we’re past the worst).
I felt a bit rough yesterday.
Temperature 36.6 C which is normal sublingual (under the tongue) reading for our thermometer.
I crushed some garlic (oh 1st world problems not being able to find the inner bit of the garlic press).
Whilst giving it 10 minutes to brew I decided digital application to the nasal mucosa might be an efficient way to use the juice, targeted application a primary infection site.
(yes—I stuck my finger in the juice and then up my nose. Different finger for each nostril, gotta maintain some standards!)
mostly studies of different types of rehydration therapies, always in children, and most for diarrhea induced imbalances rather than fever.
Any electrolyte losses due to having a fever for a few hours/days is not clinically significant which is why you can’t find relevant studies. The body is capable of coping with a bout of pyrexia.
published in 1938: ELECTROLYTE BALANCES DURING ARTIFICIAL FEVER WITH SPECIAL REFERENCE TO LOSS THROUGH THE SKIN
Plain water is usually sufficient to maintain hydration during a a fever + a little salt if sweating a lot. (I have said this before but it was voted down out of view - too simple and practical?).
Taking electrolytes (within recommended dosage) isn’t going to hurt but it is not necessary for a fever.
You’re right re the “ground glass”, it’s describing what the lung looks like on imaging and is very non-specific. (Many etiologies and a long list of differential diagnoses).
A good article re ground-glass opacification and what might have caused it.