I don’t think there was an RCT for DMT vs triptans. It’d be great to have one but I don’t think anyone ran one. There are also legal barriers to running one (which are definitely possible to overcome, but still).
Testimonials and surveys of patients are the best thing we have currently.
4-AcO-DMT is converted to psilocin (4-HO-DMT) in the body, the same way psilocybin (4-PO-DMT) does, so it’s not particularly different.
DMT is already mild when taken in doses required for this condition. If you want something even milder, 5-MeO-DALT pops up in discussions, but my impression it’s because it’s legal in many jurisdictions.
Re: psychedelic enthusiasts.overstating effects. I recommend going for the primary sources and looking up testimonials from cluster headache patients!
It feels clear to me, for example, that agentic desire is inherent to pain and suffering (there has to be a thing that wants not-that for it to count as pain/suffering).
Why is this clear? People who meditate a lot often drop their sense of agency and it does come with a layer of suffering being dropped, but the baseline experience remains.
When I experience a toothache, it just feels bad on its own, like a dissonance in my experience. And when I pinch myself to cause pain, my agentic desire is actually directed in the opposite direction of pain, but the pain still happens.
Oh interesting, thanks for the comment. I’ll think how better describe migraines then, maybe simply “there is often debilitating pain”.
How bad is a median migraine across entire population? I assumed people generally don’t function well with it, e.g. lie down to wait it out.