Dan Elton blog: https://moreisdifferent.substack.com/ website: http://www.moreisdifferent.com twitter: https://twitter.com/moreisdifferent
delton137
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I wrote a bit about this here:
https://moreisdifferent.blog/p/psychosomatic-contributors-to-long
I also recommend Steve Byrne’s analysis of his wrist pain and psychosomatic factors : https://www.lesswrong.com/posts/BgBJqPv5ogsX4fLka/the-mind-body-vicious-cycle-model-of-rsi-and-back-pain
more generally, the biopsychosocial folks seem to have the right framework for understanding complex, chronic illness.
Sorry to hear about your condition.. starting a community sounds good, I just emailed you. I went through a two year long Long COVID ordeal and now consider myself recovered. I’ve written several in-depth articles on Long COVID, and am working on a Long COVID dashboard (work in progress) to help make sense of all the trials conducted so far around the world.
Very interesting. My crude guess is not enough getting into the brain before the peptide degrades. Orexin nasal spray trials for narcolepsy have beem kind of disappointing so far, which is why companies like Takeda are developing orexin agonists.
Keep up the experimentation. I wrote about something related by the way—S-modafinil, the shorter acting enatomer of modafinil (modafinil, as you know, boosts orexin, (or orexin signaling.. something like that).. and also boosts dopamine as well).
I agree. It could be all shut down in a minute, or the FDA might have other priorities.
Regarding the concern that oral vaccines could trigger allergies—you’re not the only person who has voiced that concern. Based on my crude understanding from talking with ChatGPT briefly about this, if the vaccine targets M cells (which this one is hypothesized to do), it induces a systemic and possibly mucousal immune response, not the type of IgE mediated response that causes allergies to develop.
I think what you’re saying about vaccine hesitancy is the conventional thinking, and it’s not wrong—there is indeed a large partisan gap. I guess what I’m saying is that decentralized development of yeast-based vaccines should reduce hesitancy on the margin, given the extreme safety of subunit vaccines in general.
“Beers for Biodefense”—why yeast-based vaccines could be a big deal for biosecurity
@Raemon I think there’s a slight bug with the calendar (https://www.waypoint.lighthaven.space/e/solstice-season/schedule For me, it shows the Before Party and Speed Friending under Thurs Dec 4th and the Solstice Events under Friday Dec 5th (they are shifted back a day). (The dates on the events are correct, it is just the calendar display that is off). This might be a fluke due to my local browser environment, though.
I see it, and I can log in.
OK, I admit there was important subtext that I missed here. Mea culpa.
“If Anyone Builds it, Everyone Dies” : three AI futurists with disparate views respond—socializing, talks, and panel discussion at Microsoft NERD
A Defense of Peer Review
I’ve never heard of cyclic peptides. But I suppose it is possible.
Actually the HPLC study we cite talks about a similar possibility—they say the observed effects may be due to “cryptic peptides”, perhaps created by the lysing of larger proteins and peptides. It just seems very unlikely to me. To me, based on my metascience research, it’s a it easier to believe that the published literature is just plain wrong. Check out the HPLC paper—it’s he only we found doing that sort of analysis but it’s very detailed (https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/dta.1817).
In the case of Bryan Johnson he injected it in his glute. Others inject in the thigh (there’s a how-to video about this on YouTube). Apparently some biohackers online think that by injecting in the shoulder more will reach the brain, because the shoulder is closer to the head, according to a podcast I listened to LOL (the podcaster agreed this made a lot of sense).
Uh this is kinda embarrassing but I just didn’t really read it at all honestly..
Q: when was prion disease discoveredA: “Prion disease was first recognized as a distinct category of neurodegenerative disorders in the 1980s, though the groundwork for its discovery was laid earlier.
Key milestones in the discovery of prion diseases include:
1920s: Creutzfeldt-Jakob Disease (CJD) was first described by Hans Gerhard Creutzfeldt and Alfons Maria Jakob.
1950s: Carleton Gajdusek began studying kuru, a disease affecting the Fore people of Papua New Guinea.
1960s: Gajdusek demonstrated that kuru could be transmitted to chimpanzees, suggesting an infectious etiology.
1982: Stanley Prusiner coined the term “prion” (for proteinaceous infectious particle) and proposed the protein-only hypothesis for these infectious agents.
1997: Prusiner was awarded the Nobel Prize in Physiology or Medicine for his work on prions.
The concept of prions as the causative agents of these diseases was revolutionary because it challenged the central dogma of biology, suggesting that proteins alone, without nucleic acids, could be infectious.
Would you like me to elaborate on any specific aspect of prion disease discovery?”
You have an eagle eye Carl!… I actually asked Claude (the AI) about this when I was writing it, but I was very sloppy and didn’t read Claude’s answer carefully. Just fixed it. I should be more careful..
WTH is Cerebrolysin, actually?
AI lightning talks round 2 (ACX Boston x AICamp Boston crossover event)
Great, I look forward to meeting you there!
That’s super cool. You should headline that you’re looking at a modified peptide somewhere on Manifund (if you’re not already) -- that seems significant—I don’t know if the clinical trials on orexin do that. Tagging @gsfitzgerald in case he has thoughts (he is a neuroscience PhD student who knows a lot about peptides).
I appreciate the kind words too regarding my post!
Backing up a bit, I’m pretty skeptical of the ability to reduce sleep need generally unless you are able to increase sleep quality (or waste clearance?) to reduce necessary sleep time, but I think that’s a tall order given that sleep is orchestrated by an intricate dance of multiple neurotransmitters…
I have a long post about how I tried like 10 sleep aids—it went viral on Reddit and is the most-read thing I’ve ever written. Anyway, all sleep aids seem to extend sleep time though and many disrupt sleep cycles—so you’re sleeping longer than optimal and with poorer quality . The one that comes closest to reducing sleep need IME is dayvigo (orexin antagonist) - I generally get 7 solid hours of very high quality sleep when taking it, spending like 7.5 hours in bed, it as opposed to without it I often have a longer time in bed overall. The combo of an orexin antagonist at night and an orexin agonist in the morning intrigues me a lot—that’s actually the main reason I’m interested in your work. I know at least two people in the longevity community who now take orexin angatonists daily before bed “for neuroprotection”, and they might benefit from your work also.
Also, I really like the idea of having new tools available to safely offset occasional sleep deprivation.
I also have a friend with narcolepsy and I think any experiments with modified orexin (especially capped/modified) are very relevant to the narcolepsy community, also.