I believe that scientists can change fields easily and sometimes make bigger impact in the new fields they enter. I think it’s because people who move do not look at the same problem from the traditional point-of-view. This enables us to come up with unique solutions. We are not trapped by dogma and if we are bold we can rise quickly.
-- Aubrey de Grey
The point of this post was to show that persisting at something while being irrational can only cause harm. Of course, “Never give up” is not bad advice, but Eliezer’s advice is be rational and accept defeat when you need to.