Probably not the type of reference you were thinking about regarding reprogramming and impact on aging issues but I suspect it’s in the area you were thinking. I’m pretty sure it’s been mentioned here on LW before in other posts/comments. Interesting idea but implementation is problematic to say the least—but really hoping someone can figure it out.
Since a lot of this is way beyond my skill sets and knowledge, when you’re looking at the dynamic interplay aspect, is that purely internal to the cell or do you also look at the extra-cellular “communications”? If so, are you familiar with the Conboy’s plasma dilution experiments?
Our lab focuses on single-cell sequencing based technology development and computational methods. These methods yield a per-cell, sparse snapshot of one or more aspects of cell-intrinsic chromatin or transcriptome state. Some of us work on spatial methods, which allow tagging the profiled cells with a marker of their physical position in a tissue. Some of us also use a variety of computational methods to infer a temporal component from the snapshot data, in a manner analogous to chronophotography.
I don’t think our lab’s currently working on any inter-cellular communications, but it would be an interesting issue to work on.
Probably not the type of reference you were thinking about regarding reprogramming and impact on aging issues but I suspect it’s in the area you were thinking. I’m pretty sure it’s been mentioned here on LW before in other posts/comments. Interesting idea but implementation is problematic to say the least—but really hoping someone can figure it out.
Since a lot of this is way beyond my skill sets and knowledge, when you’re looking at the dynamic interplay aspect, is that purely internal to the cell or do you also look at the extra-cellular “communications”? If so, are you familiar with the Conboy’s plasma dilution experiments?
Our lab focuses on single-cell sequencing based technology development and computational methods. These methods yield a per-cell, sparse snapshot of one or more aspects of cell-intrinsic chromatin or transcriptome state. Some of us work on spatial methods, which allow tagging the profiled cells with a marker of their physical position in a tissue. Some of us also use a variety of computational methods to infer a temporal component from the snapshot data, in a manner analogous to chronophotography.
I don’t think our lab’s currently working on any inter-cellular communications, but it would be an interesting issue to work on.