The very simplest would be something like the lens, where there’s a single connection from an obvious root cause to a pathology.
But the real question is how many steps are involved in the “core” diseases of aging, i.e. the stuff that all shows up in progerias. I would guess on the order of ~10 steps would be the maximum depth, but there’s a lot of fan-out; any particular disease would involve another ~10 key pieces as an upper estimate . That includes things which don’t change with age but need to be understood as experimental knobs; it does not include red herrings.
What are your estimates for how many nodes / causal relationships you would need to investigate to figure out one blueprint?
The very simplest would be something like the lens, where there’s a single connection from an obvious root cause to a pathology.
But the real question is how many steps are involved in the “core” diseases of aging, i.e. the stuff that all shows up in progerias. I would guess on the order of ~10 steps would be the maximum depth, but there’s a lot of fan-out; any particular disease would involve another ~10 key pieces as an upper estimate . That includes things which don’t change with age but need to be understood as experimental knobs; it does not include red herrings.