1) I want to know enough about the low-level mechanics of gene transfer to be able to model it accurately enough (not necessarily for a scientific paper) with mathematics. This has to have been done before—links to how would be appreciated, or I could start from scratch.
2) I want to know enough about how it works on the macro level to simulate that too, perhaps with the lower level mechanics working behind the scenes.
3) I am very interested in how evolution started—Dawkins references a soup of chemicals, and then the creation of the first replicator mainly by chance over a very long period of time. Is that accurate?
How did evolution work in the beginning? Dawkins mentioned that there were other explanations than the one he gave—what are they? How do I find them?
My training is in engineering/programming, and my genetics knowledge doesn’t much exceed anything taught at the high school level. I am, however, prepared to read college-level textbooks on the subject.
My training is in engineering/programming, and my genetics knowledge doesn’t much exceed anything taught at the high school level. I am, however, prepared to read college-level textbooks on the subject.
We read this in med school, a bit too wordy for my taste but easy to understand.
I am very interested in how evolution started [...] How did evolution work in the beginning?
Nobody knows for sure. The primordial soup is just an educated guess based on the fact that complex molecules had to arise from simpler ones. This paper focuses on the evolution of multicellularity and briefly references other necessary milestones in early evolution.
3) I am very interested in how evolution started—Dawkins references a soup of chemicals, and then the creation of the first replicator mainly by chance over a very long period of time. Is that accurate?
You are not the only one. :)
Most of the current thinking around abiogenesis involves the so-called ‘RNA world’, after observations of messenger RNA molecules (a single strand of ‘naked’ genetic polymer floating around the cell, rather than the double DNA helix). Because complementary nucleotides attract one another to varying degrees, a given nucleotide sequence in mRNA will clump the molecule up in a predictable way. Also, an ‘unraveled’ mRNA molecule would tend to attract complementary nucleotides from outside the molecule and align them in to a similar polymer. In a nucleotide-rich environment, mRNA might be capable of reproduction. Therefore, within the scope of a single molecule, you have a genotype that is directly expressed with a phenotype, and that phenotype would affect the lifespan of the molecule and therefore its chances of reproduction- a plausible origin for natural selection.
My favorite treatment of this scenario (and its problems) is found in Major Transitions in Evolution, also by John Maynard Smith. There’s also Origins of Order by Kauffman, although it’s a much more theoretical treatment, and I’m not sure the returns on investment are all that good.
What do you actually want to know about evolution? How much genetics do you know?
I’ll try to summarize:
1) I want to know enough about the low-level mechanics of gene transfer to be able to model it accurately enough (not necessarily for a scientific paper) with mathematics. This has to have been done before—links to how would be appreciated, or I could start from scratch.
2) I want to know enough about how it works on the macro level to simulate that too, perhaps with the lower level mechanics working behind the scenes.
3) I am very interested in how evolution started—Dawkins references a soup of chemicals, and then the creation of the first replicator mainly by chance over a very long period of time. Is that accurate?
How did evolution work in the beginning? Dawkins mentioned that there were other explanations than the one he gave—what are they? How do I find them?
My training is in engineering/programming, and my genetics knowledge doesn’t much exceed anything taught at the high school level. I am, however, prepared to read college-level textbooks on the subject.
Thanks.
We read this in med school, a bit too wordy for my taste but easy to understand.
Nobody knows for sure. The primordial soup is just an educated guess based on the fact that complex molecules had to arise from simpler ones. This paper focuses on the evolution of multicellularity and briefly references other necessary milestones in early evolution.
You are not the only one. :)
Most of the current thinking around abiogenesis involves the so-called ‘RNA world’, after observations of messenger RNA molecules (a single strand of ‘naked’ genetic polymer floating around the cell, rather than the double DNA helix). Because complementary nucleotides attract one another to varying degrees, a given nucleotide sequence in mRNA will clump the molecule up in a predictable way. Also, an ‘unraveled’ mRNA molecule would tend to attract complementary nucleotides from outside the molecule and align them in to a similar polymer. In a nucleotide-rich environment, mRNA might be capable of reproduction. Therefore, within the scope of a single molecule, you have a genotype that is directly expressed with a phenotype, and that phenotype would affect the lifespan of the molecule and therefore its chances of reproduction- a plausible origin for natural selection.
My favorite treatment of this scenario (and its problems) is found in Major Transitions in Evolution, also by John Maynard Smith. There’s also Origins of Order by Kauffman, although it’s a much more theoretical treatment, and I’m not sure the returns on investment are all that good.