How to plan for a radically uncertain future?

While playing around with Stable Diffusion last week I had an epiphany. I realized that while I believe with high probability that the world will be radically different in 15 years, all my investments, living arrangements, and other long term plans implied a belief that the world would be roughly similar to now. This shook me to my core.

More concretely, I have investments in suburban American property, a 401k plan that I maximize and invest in a broadly diversified low cost fund, many children whom I educate in roughly conventional subjects (from college age down to toddler age), and a job that I intend to keep for the long term. But I believe there is a less than 1% probability that my 401k will mean anything by the time I can withdraw it. I don’t believe that my property (or any suburban American property) will be valuable in 15 years under most scenarios I consider likely. I don’t think my children’s education will serve them particularly well during their adulthood.

What are my beliefs about the future? I believe that AI and biology at least (two subjects I know well and follow closely) are accelerating quickly, with logarithmic increases of capability and similar log decreases of cost. I believe that it is early days for both fields, and these log curves will be extended further for years to come.

Given those beliefs, the thing I expect most is radical change, in a direction that I can’t predict well. I’m not biased towards a doom scenario (AI takeover, engineered unstoppable plague), nor towards a utopian scenario (beneficent AGI, biological immortality). But I am biased strongly away from the continuation of the status quo, away from any regime where I can sell my house, live off my 401k, watch my children take jobs that exist today and have their own families.

I suspect others here hold similar beliefs about the future. How are you preparing now? How do you invest, how do you rear your young, what actions do you take that let you sleep well, knowing that whatever tomorrow brings your rationality has armed you in advance?