I know Genomic Prediction at least has used “Quality Adjusted Lifespan” in their past papers, so I think they’re used interchangeably.
Both they and Orchid provide the expected absolute lifetime risk of each disease in their reports, so parents can re-prioritize embryo implantation according to their preferences. Doing this methodically is pretty tricky though; every disease has a different age of onset distribution and a different impact on life expectancy and quality of life.
My hope is that one or both of them create more granular tools to help patients pick embryos according to their values and preferences. But so far the best you can do is just looking at the raw numbers and googling stuff about average age of onset etc.
Oh, so the option to choose all of those disease weights is there, it’s just a lot of effort for the parents? That’s good to know.
Yeah, ideally it shouldn’t need to be done by each parents separately, but rather there should be existing analyses ready. And even if those orgs don’t provide a satisfactory analyses themselves, they could be done independently. F.e. collaborating on that with Happier Lives Institute could work well, as they have some similar expertise.
No, the option to select against all diseases in proportion to their impact on quality-adjusted lifespan is the default. But parents can re-do the calculation to like take age of onset into account if they want. Or they could add other non-disease traits to their selection criteria (like intelligence, as estimated by some third party service).
I agree, it’s very sub-optimal for parents to have to do all this themselves.
It’s a pity they don’t use some more accurate well-being metrics like f.e. WELLBY (although I think WELLBY isn’t ideal either).
How much control do the parents have on what metric will be used to rank the embryos?
I know Genomic Prediction at least has used “Quality Adjusted Lifespan” in their past papers, so I think they’re used interchangeably.
Both they and Orchid provide the expected absolute lifetime risk of each disease in their reports, so parents can re-prioritize embryo implantation according to their preferences. Doing this methodically is pretty tricky though; every disease has a different age of onset distribution and a different impact on life expectancy and quality of life.
My hope is that one or both of them create more granular tools to help patients pick embryos according to their values and preferences. But so far the best you can do is just looking at the raw numbers and googling stuff about average age of onset etc.
Oh, so the option to choose all of those disease weights is there, it’s just a lot of effort for the parents? That’s good to know.
Yeah, ideally it shouldn’t need to be done by each parents separately, but rather there should be existing analyses ready. And even if those orgs don’t provide a satisfactory analyses themselves, they could be done independently. F.e. collaborating on that with Happier Lives Institute could work well, as they have some similar expertise.
No, the option to select against all diseases in proportion to their impact on quality-adjusted lifespan is the default. But parents can re-do the calculation to like take age of onset into account if they want. Or they could add other non-disease traits to their selection criteria (like intelligence, as estimated by some third party service).
I agree, it’s very sub-optimal for parents to have to do all this themselves.