No, replication is more robust than that. I have never heard of large insertion or deletion in replication, except in highly repetitive regions (and there only dozens of bases, I think).
However, meiotic crossover is sloppy, providing the necessary variation.
Speaking of meiotic crossover, non-coding DNA provides space between coding regions, reducing the likelihood of crossover breaking them.
No, replication is more robust than that. I have never heard of large insertion or deletion in replication, except in highly repetitive regions (and there only dozens of bases, I think).
However, meiotic crossover is sloppy, providing the necessary variation.
Speaking of meiotic crossover, non-coding DNA provides space between coding regions, reducing the likelihood of crossover breaking them.
Meiotic crossover is what I meant, actually. Generally the polymerase itself wouldn’t skip unless the region is highly repetitive, you’re right.