So you’re saying that the persistent epigenetic modification is a change in the “equilibrium state” of a potentially methylated location?
Yes.
Does this mean that the binding affinity of the location is the property that changes?
Not quite, it would most likely be a change in concentrations of enzymes or cofactors or whatever which methylate/demethylate the specific site (or some set of specific sites), rather than a change in the site itself.
Yes.
Not quite, it would most likely be a change in concentrations of enzymes or cofactors or whatever which methylate/demethylate the specific site (or some set of specific sites), rather than a change in the site itself.