Depending on what you meant by “we should start with” this comment might not apply.
I would think an interesting comparison to add to the argument’s in the OP (And, I thought it a good call out. Thanks.) might be looking at IGF-1 in naked mole-rats. They seem to have a good track record with respect to aging processes. If they don’t show the implied relation between IGF-1 and their good aging attribute then why expect that in dog, or cats, other pet animals (or farm animals) or humans?
Very late response but that was just saying, from my cursory knowledge, that everyone seems to agree that naked mole-rats do not seem to display the same aging related problems other species do.
Naked mole rats exhibit unique characteristics related to Insulin-like Growth Factor 1 (IGF-1). These animals are known for their exceptionally long lifespans relative to their size and their remarkable resistance to cancer. Studies have shown that differences in the IGF-1 pathway in naked mole rats contribute to these traits.
IGF-1, a hormone similar in molecular structure to insulin, plays a significant role in growth during childhood and continues to have anabolic effects in adults. In most mammals, including humans, IGF-1 is a critical component in the regulation of growth and development, and it has been implicated in the aging process and cancer development.
In naked mole rats, however, there are several unique aspects:
Reduced IGF-1 Signaling: Naked mole rats have lower levels of IGF-1 and reduced IGF-1 signaling compared to other mammals. This reduced signaling is thought to contribute to their slow growth rates and small adult size.
Longevity and Aging: The altered IGF-1 pathway in naked mole rats is believed to be one of the factors contributing to their extended lifespan and healthspan. In many species, reduced IGF-1 signaling is associated with longer lifespans, and this seems to be the case with naked mole rats as well.
Cancer Resistance: Naked mole rats are remarkably resistant to cancer, and this resistance is partly attributed to their unique IGF-1 signaling pathways. Their cells have a heightened sensitivity to contact inhibition, a process where cells stop growing when they come into contact with each other, which is a mechanism that can prevent cancerous growth.
Metabolic Stability: Naked mole rats maintain stable metabolic rates and body temperatures, despite living in fluctuating underground environments. This stability might be influenced by their unique hormonal regulation, including IGF-1.
Overall, the unique aspects of IGF-1 in naked mole rats are a significant area of research, especially in the context of aging, cancer biology, and understanding the mechanisms of longevity.
Depending on what you meant by “we should start with” this comment might not apply.
I would think an interesting comparison to add to the argument’s in the OP (And, I thought it a good call out. Thanks.) might be looking at IGF-1 in naked mole-rats. They seem to have a good track record with respect to aging processes. If they don’t show the implied relation between IGF-1 and their good aging attribute then why expect that in dog, or cats, other pet animals (or farm animals) or humans?
What is “a good track record with respect to aging processes” referring to?
Very late response but that was just saying, from my cursory knowledge, that everyone seems to agree that naked mole-rats do not seem to display the same aging related problems other species do.
ChatGPT’s opinion on IGF-1 in naked mole rats: