On the other hand: half of mouse studies working in humans is an extremely good success rate. We should be quite suspicious of file-drawer effects and p-hacking.
I agree the effect is consistent enough that we should be suspicious of file drawer/p-hacking—although that’s also what you’d expect to see if the effect were in fact large—but note that they were different studies, i.e. the human studies mostly weren’t based on the non-human ones.
I was initially very concerned about this but then noticed that almost all the tested secondary endpoints were positive in the mice studies too. The human studies could plausibly still be meaningless though.
Has anyone (esp you Jim) looked into fecal transplants for this instead, in case our much longer digestive system is a problem?
On the other hand: half of mouse studies working in humans is an extremely good success rate. We should be quite suspicious of file-drawer effects and p-hacking.
I agree the effect is consistent enough that we should be suspicious of file drawer/p-hacking—although that’s also what you’d expect to see if the effect were in fact large—but note that they were different studies, i.e. the human studies mostly weren’t based on the non-human ones.
I was initially very concerned about this but then noticed that almost all the tested secondary endpoints were positive in the mice studies too. The human studies could plausibly still be meaningless though.
Has anyone (esp you Jim) looked into fecal transplants for this instead, in case our much longer digestive system is a problem?