I found that section a useful summary which didn’t require a lot of background. Parts that stood out, without quoting the entire thing:
OP’s claim number one: Open Philanthropy’s list of selected topics and the SENS’ plan differ in focus.
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If Open Philanthropy had said that what SRF is funding right now differs in focus with their list of selected topics, I would agree.
OP’s claim number two: Open Philanthropy, unlike SRF, doesn’t claim that progress on the topics they identified would be sufficient to make aging negligible in humans.
What SRF claims is that solving all the seven categories will probably lead to lifespans longer than the current maximum. After that, what other forms of damages will appear is not known, but at that point, those additional damages may be cured (maybe through a SENS 2.0 panel of therapies) during the time “bought” by the first therapies and through their improvement.
Aubrey de Grey can often be heard making another claim that may prove confusing. He says: “Since no other damage has been discovered in decades, it is more and more probable that the SENS list is complete”. “Complete” here means that it is the complete list of things that go wrong in a normal human lifespan. It’s clear that we currently can’t acquire direct data about what will go wrong after the current maximum human lifespan is exceeded.
I found that section a useful summary which didn’t require a lot of background. Parts that stood out, without quoting the entire thing: