There are cases where there’s a lot of evidence that “standard” cut-offs are in the wrong place. “Subclinical hypothyroidism” still benefits from supplemental thyroid hormone; higher-than-standard doses of allopurinol control gout better; “standard” light therapy for seasonal affective disorder doesn’t work as well as ultra-bright lights; etc. More Dakka.
This sounds like a job for Sarah Constantin, formerly of MetaMed...
She’s seems to agree there’s an issue:
(from https://srconstantin.wordpress.com/2019/03/04/personalized-medicine-for-real/)
If anyone can stick this post and the follow-up in front of someone open-minded and competent, I’d love to hear their reactions to it!