Chronotherapy is the idea that time of day matters for things like taking drugs or getting vaccinations, and chronoimmunology is a related field for how your immune system varies in effectiveness over the course of the day. I’ve been wanting to write about this since there’s definitely a best time of day to take drugs, get vaccines, and do social activities without getting sick… but unfortunately I don’t really know what that time is.
Some studies say your immune system is most primed to prevent infection right as you wake up, and other say mid-day. Of course half the studies are in mice. Maybe it depends on the disease and the chronotype? See this review.
One study says that vaccines work better in the morning (for older patients). Another says there’s no difference. Maybe this has something to do with the particular vaccines, or maybe the populations (different circadian rhythms, more powerful circadian rhythms). Weirdly, our priors say vaccination should work best mid-day but most people don’t even try that. See this review.
I find this all really interesting, and there’s probably a practical takeaway, but I don’t know what it is. I guess we can be pretty confident that you shouldn’t get vaccines in the middle of the night.
Maybe someone can convince Elizabeth to look into this.
Chronotherapy is the idea that time of day matters for things like taking drugs or getting vaccinations, and chronoimmunology is a related field for how your immune system varies in effectiveness over the course of the day. I’ve been wanting to write about this since there’s definitely a best time of day to take drugs, get vaccines, and do social activities without getting sick… but unfortunately I don’t really know what that time is.
Some studies say your immune system is most primed to prevent infection right as you wake up, and other say mid-day. Of course half the studies are in mice. Maybe it depends on the disease and the chronotype? See this review.
One study says that vaccines work better in the morning (for older patients). Another says there’s no difference. Maybe this has something to do with the particular vaccines, or maybe the populations (different circadian rhythms, more powerful circadian rhythms). Weirdly, our priors say vaccination should work best mid-day but most people don’t even try that. See this review.
I find this all really interesting, and there’s probably a practical takeaway, but I don’t know what it is. I guess we can be pretty confident that you shouldn’t get vaccines in the middle of the night.
Maybe someone can convince Elizabeth to look into this.