I’m not certain this is a big problem, but it can be. My guess is 60% that this causes a significant increase in oral cancers for ALDH deficiency heterozygotes.
If you add up the upper digestive tract cancers, it looks like 2.7% developing and 0.8% dying for men, and 1.4% developing and 0.5% dying for women.
It’s worse than cervical cancer (0.6/0.2%), even if you only consider oral/esophageal for women.
Yep, that’s an alarmingly high base rate, so multiplying that by ten is an enormous added risk. So even if the concentration and effect is far lower than in alcoholics, I’d still probably not take that risk.
I’m not certain this is a big problem, but it can be. My guess is 60% that this causes a significant increase in oral cancers for ALDH deficiency heterozygotes.
If you add up the upper digestive tract cancers, it looks like 2.7% developing and 0.8% dying for men, and 1.4% developing and 0.5% dying for women.
It’s worse than cervical cancer (0.6/0.2%), even if you only consider oral/esophageal for women.
Yep, that’s an alarmingly high base rate, so multiplying that by ten is an enormous added risk. So even if the concentration and effect is far lower than in alcoholics, I’d still probably not take that risk.
Possibly even without ALDH deficiency.