I gave you a worked example, with real empirical data: achondroplasia has a spontaneous rate of 3⁄100,000. Try to understand the example rather than pulling facts out of your head with no understanding.
The rate of spontaneous mutation in humans is on the order of 10^-8 per haploid base-pair per generation. A few references: one (a blog post summarizing multiple academic papers), two (I think this is one of the papers cited by the foregoing), three (older; rate is ~2x higher), four (intermediate in age and also in estimated rate).
A given gene is many base-pairs long. Accordingly, the “per locus” mutation rate—which you can think of as how often a particular gene goes wrong, treating all its failure modes as equivalent—is on the order of 1000x higher. (This, I take it, is where the ~3x10^-5 spontaneous rate for achondroplasia comes from.) The usual cited per-locus rates are, accordingly, on the order of 10^-5, typically a bit lower; see e.g. one (a textbook, which specifically mentions achondroplasia and gives some reasons not to take its rate of spontaneous occurrence too literally as a per-locus mutation rate), two (old paper by J B S Haldane, mostly of historical interest now), three (journal article).
Which figure is more relevant in a given case depends on whether it’s one where messing up a single protein, no matter how, causes the effect you’re interested in (which seems to be the case for achondroplasia) or one where a very specific change is needed. Which is more likely for homosexuality? I’ve no idea; more likely than either, I’d have thought, is that sexuality is complicated, that there are lots of genetic changes that can affect someone’s propensity for same-sex attraction, and that treating homosexuality as the result of a single genetic change is just wrong.
Anyway, to summarize: no one, so far as I can tell, says that 10^-4 is “the standard rule-of-thumb mutation rate”, either per locus or per nucleotide; 10^-8 is roughly the right figure per nucleotide; the right figure per locus is more like 10^-5; which of these figures, if either, is most relevant when considering homosexuality is unclear but for any remotely credible figure it’s clear that most homosexuality is not the result of spontaneous mutations.
Nope, that’s the wrong rate.
I gave you a worked example, with real empirical data: achondroplasia has a spontaneous rate of 3⁄100,000. Try to understand the example rather than pulling facts out of your head with no understanding.
That seems needlessly inflammatory.
The rate of spontaneous mutation in humans is on the order of 10^-8 per haploid base-pair per generation. A few references: one (a blog post summarizing multiple academic papers), two (I think this is one of the papers cited by the foregoing), three (older; rate is ~2x higher), four (intermediate in age and also in estimated rate).
A given gene is many base-pairs long. Accordingly, the “per locus” mutation rate—which you can think of as how often a particular gene goes wrong, treating all its failure modes as equivalent—is on the order of 1000x higher. (This, I take it, is where the ~3x10^-5 spontaneous rate for achondroplasia comes from.) The usual cited per-locus rates are, accordingly, on the order of 10^-5, typically a bit lower; see e.g. one (a textbook, which specifically mentions achondroplasia and gives some reasons not to take its rate of spontaneous occurrence too literally as a per-locus mutation rate), two (old paper by J B S Haldane, mostly of historical interest now), three (journal article).
Which figure is more relevant in a given case depends on whether it’s one where messing up a single protein, no matter how, causes the effect you’re interested in (which seems to be the case for achondroplasia) or one where a very specific change is needed. Which is more likely for homosexuality? I’ve no idea; more likely than either, I’d have thought, is that sexuality is complicated, that there are lots of genetic changes that can affect someone’s propensity for same-sex attraction, and that treating homosexuality as the result of a single genetic change is just wrong.
Anyway, to summarize: no one, so far as I can tell, says that 10^-4 is “the standard rule-of-thumb mutation rate”, either per locus or per nucleotide; 10^-8 is roughly the right figure per nucleotide; the right figure per locus is more like 10^-5; which of these figures, if either, is most relevant when considering homosexuality is unclear but for any remotely credible figure it’s clear that most homosexuality is not the result of spontaneous mutations.
[EDITED to fix a typo.]