Another relevant paper is Effect of aging on stem cells. Stem cells are the foundation of cell turnover. Yet their capacity to proliferate and differentiate deteriorates with age. This seems like it’s getting closer to a root cause of breakdown of a major aging defense mechanism. Might be a high-value node to understand and prevent aging.
Edit: I see you covered this to some extent in your “Core Pathways of Aging” post.
Another relevant paper is Effect of aging on stem cells. Stem cells are the foundation of cell turnover. Yet their capacity to proliferate and differentiate deteriorates with age. This seems like it’s getting closer to a root cause of breakdown of a major aging defense mechanism. Might be a high-value node to understand and prevent aging.
Edit: I see you covered this to some extent in your “Core Pathways of Aging” post.