model trained on RNA-seq cell data and different cell types, growth environments, states (cancer vs not), and drug exposures successfully predicted a drug that enhanced antigen presentation, making “cold” cancer cells “hot” enough to be more susceptible to immunotherapy.
“hm, someone thoughtful recommended this sermon, maybe it has advice I could take to heart? wow, guess not.”
“They [rich people] desire and mean to serve God, nay actually do serve Him in their measure; but not with the keen sensibilities, the noble enthusiasm, the grandeur and elevation of soul, the dutifulness and affectionateness towards Christ which become a Christian, but as Jews might obey, who had no Image of God given them except this created world, “eating their bread with joy, and drinking their wine with a merry heart,” caring that “their garments be always white, and their head lacking no ointment, living joyfully with the wife whom they love all the days of the life of their vanity,” and “enjoying the good of their labour.” [Eccles. ix. 7-9; v. 18.] Not, of course, that the due use of God’s temporal blessings is wrong, but to make them the object of our affections, to allow them to beguile us from the “One Husband” to whom we are espoused, is to mistake the Gospel for Judaism.”
IMO, if the First Amendment means that unsavory AI “speech” must be legal, then so be it. Civil liberties are that important. But then private institutions and individuals are going to need to fill that gap by deciding for themselves when to say no to AI. if you ever really need to know that text wasn’t AI-generated, you may need to be much more careful about provenance, e.g. ensuring that it was entirely hand-written, or only made on computers without internet connections, or things like that.
Many people have commented that “liberals are more unhappy than conservatives” is a pretty robust finding when measured different ways, and one contradictory study doesn’t disprove it. On the other hand I do think there are hard-to-capture nuances about what this piece calls “externalizing.”
Two people may be “actually” equally unhappy, but the person who places a high value on expressing feelings may describe themselves as unhappy, whereas the person who thinks it’s superior to be stoic or cheerful may say they feel fine while actually having an elevated heart rate, tense body language, a stressed tone of voice, little ability to enjoy anything, etc.
Right and left definitely have different values around unhappiness; from a left perspective, expressed unhappiness is grounds for sympathy (all else being equal), whereas from a right perspective, it’s more likely to be seen as grounds for blame. This is very hard to disentangle from how people actually feel. Does the judgment “complaining of unhappiness is blameworthy” cause people to feel happier? Does it cause them to feel the same but complain less? Does it attract people who are happier to begin with?
claims that Biden intended to be more immigration-restrictionist than his administration actually was. that, regardless of your view on what the best policy is, there was the same sort of ineffectual slowness in taking executive actions going on with immigration that people complain of with things like building infrastructure.
not a huge fan of these opinions (they’re consistently grouchy, and either obvious or not credible), but truly anonymous blogging in the old-fashioned style is rare these days so props for that
links 10/17/2025: https://roamresearch.com/#/app/srcpublic/page/10-17-2025
https://blog.google/technology/ai/google-gemma-ai-cancer-therapy-discovery/
model trained on RNA-seq cell data and different cell types, growth environments, states (cancer vs not), and drug exposures successfully predicted a drug that enhanced antigen presentation, making “cold” cancer cells “hot” enough to be more susceptible to immunotherapy.
https://www.newmanreader.org/works/parochial/volume2/sermon28.html
“hm, someone thoughtful recommended this sermon, maybe it has advice I could take to heart? wow, guess not.”
“They [rich people] desire and mean to serve God, nay actually do serve Him in their measure; but not with the keen sensibilities, the noble enthusiasm, the grandeur and elevation of soul, the dutifulness and affectionateness towards Christ which become a Christian, but as Jews might obey, who had no Image of God given them except this created world, “eating their bread with joy, and drinking their wine with a merry heart,” caring that “their garments be always white, and their head lacking no ointment, living joyfully with the wife whom they love all the days of the life of their vanity,” and “enjoying the good of their labour.” [Eccles. ix. 7-9; v. 18.] Not, of course, that the due use of God’s temporal blessings is wrong, but to make them the object of our affections, to allow them to beguile us from the “One Husband” to whom we are espoused, is to mistake the Gospel for Judaism.”
https://marginalrevolution.com/marginalrevolution/2025/10/ai-and-the-first-amendment.html
IMO, if the First Amendment means that unsavory AI “speech” must be legal, then so be it. Civil liberties are that important. But then private institutions and individuals are going to need to fill that gap by deciding for themselves when to say no to AI. if you ever really need to know that text wasn’t AI-generated, you may need to be much more careful about provenance, e.g. ensuring that it was entirely hand-written, or only made on computers without internet connections, or things like that.
https://www.derekthompson.org/p/why-are-liberals-more-depressed
Many people have commented that “liberals are more unhappy than conservatives” is a pretty robust finding when measured different ways, and one contradictory study doesn’t disprove it. On the other hand I do think there are hard-to-capture nuances about what this piece calls “externalizing.”
Two people may be “actually” equally unhappy, but the person who places a high value on expressing feelings may describe themselves as unhappy, whereas the person who thinks it’s superior to be stoic or cheerful may say they feel fine while actually having an elevated heart rate, tense body language, a stressed tone of voice, little ability to enjoy anything, etc.
Right and left definitely have different values around unhappiness; from a left perspective, expressed unhappiness is grounds for sympathy (all else being equal), whereas from a right perspective, it’s more likely to be seen as grounds for blame. This is very hard to disentangle from how people actually feel. Does the judgment “complaining of unhappiness is blameworthy” cause people to feel happier? Does it cause them to feel the same but complain less? Does it attract people who are happier to begin with?
https://www.scopeofwork.net/on-factory-tours/ factory tours used to be popular tourist attractions!
https://magicsearch.sofiavanhanen.fi/ search for recommended Twitter accounts based on your interests
https://www.slowboring.com/p/what-went-wrong-with-biden-and-immigration
claims that Biden intended to be more immigration-restrictionist than his administration actually was. that, regardless of your view on what the best policy is, there was the same sort of ineffectual slowness in taking executive actions going on with immigration that people complain of with things like building infrastructure.
https://www.humaninvariant.com/blog
not a huge fan of these opinions (they’re consistently grouchy, and either obvious or not credible), but truly anonymous blogging in the old-fashioned style is rare these days so props for that
https://www.aipolicyperspectives.com/p/maintaining-agency-and-control-in good AI thoughts by Seb Krier
https://www.uncertainupdates.com/p/how-i-became-a-5x-engineer-with-claude how Gordon Worley does programming with AI.