https://backofmind.substack.com/p/the-myth-of-merit-in-the-managerial this is probably the best defense of affirmative action—‘you weren’t that good at picking the best anyway, it’s mostly biases and vibes, so you may as well decide to correct historical inequities’. i think even to the extent this is true you could argue that the policies actually enacted were unwise, but i do think it’s a point worth addressing.
links 1/11/26: https://roamresearch.com/#/app/srcpublic/page/01-11-2026
https://www.science.org/doi/full/10.1126/sciadv.aaw7243 TRPM7 is involved in mechanosensing
https://karger.com/cpb/article-abstract/19/1-4/1/207934/Direct-Mechano-Stress-Sensitivity-of-TRPM7-Channel
https://link.springer.com/article/10.1007/s12032-017-0987-1 TRPM7 is involved in the epithelial-mesenchymal transition in multiple tumor types
https://journals.sagepub.com/doi/full/10.3233/CBM-190666
https://aacrjournals.org/cancerres/article/72/16/4250/575870/TRPM7-Is-Required-for-Breast-Tumor-Cell
https://www.sciencedirect.com/science/article/pii/S0006295223004483
pharmacologically targeting TRPM7 https://www.nature.com/articles/s41467-023-38362-3
DRP1 and mitochondrial fission in cancer https://www.sciencedirect.com/science/article/abs/pii/S0304419X25001957
DNML1 in cancer https://pmc.ncbi.nlm.nih.gov/articles/PMC11540555/
the anti-apoptotic protein FLIP as a cancer target https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.14523
https://www.tandfonline.com/doi/full/10.2147/JIR.S519885
https://www.tandfonline.com/doi/abs/10.1517/14728222.2013.736499
GUK1 and cancer: https://pmc.ncbi.nlm.nih.gov/articles/PMC12148050/
ELL, involved in the elongation phase in transcription, in cancer: https://www.nature.com/articles/nrc2915
SEPHS2 & selenium metabolism in cancer: https://www.sciencedirect.com/science/article/pii/S0006497118585554
https://link.springer.com/article/10.1007/s00109-025-02563-8
https://www.nature.com/articles/s42255-020-0224-7
https://www.nature.com/articles/s41598-019-52718-0
trial of transferrin receptor drug in cancer: https://ashpublications.org/blood/article/144/Supplement%201/1496/531990/Results-of-a-Phase-1-First-in-Human-Study-of-INA03
more on transferrin & cancer: https://www.sciencedirect.com/science/article/abs/pii/S0304416511001826
NMT1, myristoylation, and cancer: https://www.nature.com/articles/s41598-025-13529-8
and phase 1 trial of drug with this target: https://link.springer.com/article/10.1007/s10637-024-01448-w
ADSL and cancer
https://onlinelibrary.wiley.com/doi/pdf/10.1002/hep.31685
PH5A and cancer: https://www.nature.com/articles/s41598-023-44899-6
https://link.springer.com/content/pdf/10.1186/s12885-024-12620-z.pdf
https://link.springer.com/content/pdf/10.1186/s12967-022-03821-w.pdf
YRDC and cancer: https://onlinelibrary.wiley.com/doi/full/10.1002/cnr2.70325
https://www.nature.com/articles/s43018-024-00748-7
https://platform.opentargets.org/ Open Targets Platform, info about many drug targets
https://depmap.org/portal/ DepMap, cancer dependency database
https://www.hyperdimensional.co/p/among-the-agents how Dean Ball uses Claude Code
https://marginalrevolution.com/marginalrevolution/2026/01/the-tyranny-of-the-complainers.html most complaints to government agencies come from a few very active complainers
https://x.com/mollycantillon/status/2008918474006122936?s=20 account (AI-written?) of how someone uses Claude Code for everything. seems potentially appealing
https://www.alexkesin.com/p/a-better-proxy-than-the-rat-and-dog foundation models for toxicology
https://www.asimov.press/p/research-forms metascience
https://archive.ph/20260108173745/https://www.washingtonpost.com/opinions/2026/01/07/ice-minneapolis-shooting-deportaitons-escalation/ this is scary
https://backofmind.substack.com/p/the-myth-of-merit-in-the-managerial this is probably the best defense of affirmative action—‘you weren’t that good at picking the best anyway, it’s mostly biases and vibes, so you may as well decide to correct historical inequities’. i think even to the extent this is true you could argue that the policies actually enacted were unwise, but i do think it’s a point worth addressing.