What’s being measured? If people go out of lockdown and interact more after being vaccinated, I could see it. That does require the people who aren’t vaccinated to not do that stuff too though.
Iirc they also did not control for previous infection. My model of why “VE” went negative is due to “natural” versus vaccinated immunity, with natural immunity lasting longer and/or generalizing better to new variants (at the cost of much higher disease burden coming into present conditions).
I was confused about what how exactly they computed VE, however, so I might just be missing something.
I’ll note that even with waning immunity, I expect vaccination to have been and remain a clear net positive to my health. I’m more on the fence for boosters because I am young male and healthy, and omicron may well be milder than some future variant, and I expect it to provide better immunity in the future. If I’m wrong about any points in that chain of “and”s, however, I expect to be wrong in a way that favors getting boosted.
What’s being measured? If people go out of lockdown and interact more after being vaccinated, I could see it. That does require the people who aren’t vaccinated to not do that stuff too though.
Iirc they also did not control for previous infection. My model of why “VE” went negative is due to “natural” versus vaccinated immunity, with natural immunity lasting longer and/or generalizing better to new variants (at the cost of much higher disease burden coming into present conditions). I was confused about what how exactly they computed VE, however, so I might just be missing something.
I’ll note that even with waning immunity, I expect vaccination to have been and remain a clear net positive to my health. I’m more on the fence for boosters because I am young male and healthy, and omicron may well be milder than some future variant, and I expect it to provide better immunity in the future. If I’m wrong about any points in that chain of “and”s, however, I expect to be wrong in a way that favors getting boosted.