Yeah the paper seems more like a material science paper than a biology paper. There was no test/simulations/discussion about biological function; similar to DNA computing/data storage, it’s mostly interested in the properties of the material than how it interfaces with pre-existing biology.
They did optimize for foldability, and did successfully produce the folded protein in (standard bacterial) cells. So it can be produced by biological systems (at least briefly), and more complex proteins had lower yields.
Their application they looked at was hydrogels, and it seems to have improved performance there? But functioning in biological systems introduces more constraints.
Yeah the paper seems more like a material science paper than a biology paper. There was no test/simulations/discussion about biological function; similar to DNA computing/data storage, it’s mostly interested in the properties of the material than how it interfaces with pre-existing biology.
They did optimize for foldability, and did successfully produce the folded protein in (standard bacterial) cells. So it can be produced by biological systems (at least briefly), and more complex proteins had lower yields.
Their application they looked at was hydrogels, and it seems to have improved performance there? But functioning in biological systems introduces more constraints.