The putative method by which leucovorin (folinic acid) might be a cure for some subtype of autism is that folate receptor autoantibodies (FRAAs) block normal sources of folate reaching the brain, causing a form of Cerebral Folate Deficiency (CFD). It’s claimed that folinic acid is an atypical source of folate which can still reach the brain in someone with those antibodies. On this theory, that subtype of autism is an autoimmune disease.
No conclusive evidence links vaccinations to autoimmune diseases, but conditional on folinic acid working, we should maybe look more closely at what would cause the autoimmune disorder, and update positively on some version of the vaccine theory?
Autism has a very strong genetic component to it, vaccines don’t have any effect over heredity
As for CFD it seems to be a genetic condition as well, a result of a mutation in the FOLR 1 gene and it is incredibly rare it can’t explain any sizable fraction of autisms prevalence
At best you could hypothesize that CFD is more prevalent then originally thought and due to similarities in the symptoms some individuals with CFD are accidentally diagnosed witb Autism instead but i don’t see how vaccines have anything to do with this
Specifically the folinic acid hypothesis is that this is an atypical autoimmune-instigated form of CFD, not the genetic type which typically manifests very rapidly. Look up Folate Receptor Alpha Autoantibodies. My strongest claim is that something environmental may be causing an uptick in autism, even accounting for its strong heritability; with a subset of that claim being “maybe vaccines”. I don’t believe this strongly enough to write more than a shortform pondering it.
The “rise” in autism’s prevalence is far more easily explain by a mix of better diagnosis and a more tolerant attitude towards autistic individuals allowing them to reproduce, especially when you consider that the rates of autism don’t differ all that much between the developed and the developing world
Plus the primary candidate mechanism for autisms symptoms is a lack of synaptic pruning not the lack of a particular nutrient
The putative method by which leucovorin (folinic acid) might be a cure for some subtype of autism is that folate receptor autoantibodies (FRAAs) block normal sources of folate reaching the brain, causing a form of Cerebral Folate Deficiency (CFD). It’s claimed that folinic acid is an atypical source of folate which can still reach the brain in someone with those antibodies. On this theory, that subtype of autism is an autoimmune disease.
No conclusive evidence links vaccinations to autoimmune diseases, but conditional on folinic acid working, we should maybe look more closely at what would cause the autoimmune disorder, and update positively on some version of the vaccine theory?
I don’t think so
Autism has a very strong genetic component to it, vaccines don’t have any effect over heredity
As for CFD it seems to be a genetic condition as well, a result of a mutation in the FOLR 1 gene and it is incredibly rare it can’t explain any sizable fraction of autisms prevalence
At best you could hypothesize that CFD is more prevalent then originally thought and due to similarities in the symptoms some individuals with CFD are accidentally diagnosed witb Autism instead but i don’t see how vaccines have anything to do with this
Specifically the folinic acid hypothesis is that this is an atypical autoimmune-instigated form of CFD, not the genetic type which typically manifests very rapidly. Look up Folate Receptor Alpha Autoantibodies. My strongest claim is that something environmental may be causing an uptick in autism, even accounting for its strong heritability; with a subset of that claim being “maybe vaccines”. I don’t believe this strongly enough to write more than a shortform pondering it.
I still don’t see this hypothesis going anywhere
The “rise” in autism’s prevalence is far more easily explain by a mix of better diagnosis and a more tolerant attitude towards autistic individuals allowing them to reproduce, especially when you consider that the rates of autism don’t differ all that much between the developed and the developing world
Plus the primary candidate mechanism for autisms symptoms is a lack of synaptic pruning not the lack of a particular nutrient