Solving Aging in the Age of AI

How would we know whether an intervention actually slowed or reversed aging rather than merely changing a biomarker or treating one disease?

AI can accelerate biomedical discovery, but generated hypotheses and analyses are not proof. Claims about aging require reproducible computational evidence, laboratory validation, testing in living systems, and measurements that remain meaningful at the individual level.

This fireside chat will examine:

How to distinguish biological aging from correlated biomarkers
How to evaluate interventions without waiting for lifetime outcomes
Reproducibility and verifiability in AI-assisted biology
Proxy measures, Goodhart’s law, and validation failure
Lifespan, healthspan, peakspan, and personalized aging measures
The path from computational discovery to biological evidence

Confirmed speakers:

Aubrey de Grey, PhD
Founder and Chief Science Officer, Longevity Escape Velocity Foundation
https://www.levf.org/aubreydegrey

Hao Li, PhD
Professor of Biochemistry and Biophysics, UCSF
Principal Investigator, Li Lab
https://profiles.ucsf.edu/hao.li
http://mobydick.ucsf.edu

Schedule:

6:00–7:00 PM — Networking and refreshments
7:00–7:45 PM — Background and science
7:45–8:00 PM — Initial Q&A
8:00–9:00 PM — Main fireside discussion
9:00–10:00 PM — Open community discussion
10:00–11:00 PM — Closing reception and informal conversations

General admission: $10
Community supporter: $25

Registration:
https://luma.com/biopunk-fireside-chat

Date and time:

Thursday, August 20, 2026
6:00–11:00 PM Pacific Time

Location:

The Fire Pit @ Biopunk House
1153 Bush Street
San Francisco, CA 94109

Organizer

Byron P. Lee
Event coordinator and curator
Founder, Cellico Bio
byron@biobitworks.com
https://cellico.bio/

Hosted by the Biopunk Community at Biopunk House.

Biopunk Community:
https://biopunk.community/

Biopunk House:
https://biopunk.house/

Biopunk Lab:
https://biopunklab.com/

Unless explicitly announced otherwise, discussions follow the Chatham House Rule. Recording, attribution, and identifiable photography require consent.

Speakers and program timing are subject to change.