Interesting! The current Sonnet 3.5 agrees (for equivalent concentrations), for the same reason you’ve described, and I was about to update the essay with a correction, but then 4o argued that 1. formaldehyde is metabolized much more quickly, so has little time to do damage or build up, and 2. that it considers formic acid’s inhibition of a critical enzyme (cytochrome c oxidase) in the mitochondrial electron transport chain to be pretty bad.
Or maybe a better summary of 4o’s argument is “In equivalent concentrations, formaldehyde is worse, but the differences in rapidity of metabolization mean formic acid builds up more and causes more damage in real-life scenarios.”
So I’ve linked your comment in the relevant section, sort of waving my hands and succumbing to both-sides-ism. Interested in what you think about the rapidity-of-metabolization argument.
Interesting! The current Sonnet 3.5 agrees (for equivalent concentrations), for the same reason you’ve described, and I was about to update the essay with a correction, but then 4o argued that 1. formaldehyde is metabolized much more quickly, so has little time to do damage or build up, and 2. that it considers formic acid’s inhibition of a critical enzyme (cytochrome c oxidase) in the mitochondrial electron transport chain to be pretty bad.
Or maybe a better summary of 4o’s argument is “In equivalent concentrations, formaldehyde is worse, but the differences in rapidity of metabolization mean formic acid builds up more and causes more damage in real-life scenarios.”
So I’ve linked your comment in the relevant section, sort of waving my hands and succumbing to both-sides-ism. Interested in what you think about the rapidity-of-metabolization argument.