I’m late to the responses here but my mind returns to your work every so often… so I tracked this down again and re-read things. Two thoughts still seem salient, which I will break into two comments in case they trigger conversations :-)
Thoughts On “NOSE COVID” And RadVac:
This entire blog post has been quite useful for refining my mechanistic models of the immune system and the fact that it has >1 compartment.
The evidence so far (especially snorting peptides with no chitosan and getting a reaction) seems to suggest to me that you did directly manage to teach your peripheral/mucosal immune system to react very quickly to the relevant protein fragments, but it seems plausible that your immunity didn’t get to the rest of the body to become systemic.
I wonder if a similar lack of “immune transfer” might hold the other way? Suppose that systemic immunity does not become mucosal?
If that supposition held, then maybe people could get “nose covid” for a few days, with an infection only in the upper respiratory system, and that might persist for however long in takes an upper respiratory version to try to invade the rest of the body, and only then trigger a systemic response?
My uncertainty is at the level of the model (two compartments… and how do they interact EXACTLY in terms of BOTH harboring independent infections AND sharing antibody notes in either direction) but some ways that the mechanisms might work suggest that nasal vaccines would actually be MORE *socially* helpful than the current “selfishly helpful” injected vaccines.
I find myself hoping that vaccines enable more travel and large safe social events in 2021, but these are exactly the kind of situations where I might want to get a mucosal vaccine to protect friends and family, like kids and any vaccine holdouts.
Basically, your mechanistic reasoning here seems highly informed, and I’m wondering if you think that “nose covid” could occur among vaccinated people, and lead to transmission chains to unvaccinated people in a way that could specifically (hopefully) be prevented specifically by a nasal spray?
I’m late to the responses here but my mind returns to your work every so often… so I tracked this down again and re-read things. Two thoughts still seem salient, which I will break into two comments in case they trigger conversations :-)
Thoughts On “NOSE COVID” And RadVac:
This entire blog post has been quite useful for refining my mechanistic models of the immune system and the fact that it has >1 compartment.
The evidence so far (especially snorting peptides with no chitosan and getting a reaction) seems to suggest to me that you did directly manage to teach your peripheral/mucosal immune system to react very quickly to the relevant protein fragments, but it seems plausible that your immunity didn’t get to the rest of the body to become systemic.
I wonder if a similar lack of “immune transfer” might hold the other way? Suppose that systemic immunity does not become mucosal?
If that supposition held, then maybe people could get “nose covid” for a few days, with an infection only in the upper respiratory system, and that might persist for however long in takes an upper respiratory version to try to invade the rest of the body, and only then trigger a systemic response?
My uncertainty is at the level of the model (two compartments… and how do they interact EXACTLY in terms of BOTH harboring independent infections AND sharing antibody notes in either direction) but some ways that the mechanisms might work suggest that nasal vaccines would actually be MORE *socially* helpful than the current “selfishly helpful” injected vaccines.
I find myself hoping that vaccines enable more travel and large safe social events in 2021, but these are exactly the kind of situations where I might want to get a mucosal vaccine to protect friends and family, like kids and any vaccine holdouts.
Basically, your mechanistic reasoning here seems highly informed, and I’m wondering if you think that “nose covid” could occur among vaccinated people, and lead to transmission chains to unvaccinated people in a way that could specifically (hopefully) be prevented specifically by a nasal spray?