“A glance at the methodology has more practical value than the little asterisk above a score at month 6.”—regarding the uselessness and distraction of p-values.
“the purpose of these studies is not to determine the answer, the purpose of these studies is to be published”
That’s actually a recurring theme in his posts. In this one he analyses the methodology of a study on a Bipolar Disorder drug. Conclusion—the authors claim the study shows that the drug is 50% more effective than a placebo. What the study actually shows, when one looks at the methodology, is that among people who responded well to the drug, 50% of them suffered relapse when the drug was discontinued. This is not surprising. And it doesn’t say what the actual efficacy of the drug is at all.
Piling on, here is Alone on diet studies:
“A glance at the methodology has more practical value than the little asterisk above a score at month 6.”—regarding the uselessness and distraction of p-values.
“the purpose of these studies is not to determine the answer, the purpose of these studies is to be published”
That’s actually a recurring theme in his posts. In this one he analyses the methodology of a study on a Bipolar Disorder drug. Conclusion—the authors claim the study shows that the drug is 50% more effective than a placebo. What the study actually shows, when one looks at the methodology, is that among people who responded well to the drug, 50% of them suffered relapse when the drug was discontinued. This is not surprising. And it doesn’t say what the actual efficacy of the drug is at all.