Curated. Genetically enhanced humans are my best guess for how we achieve existential safety. (Depending on timelines, they may require a coordinated slowdown to work). This post is a pretty readable introduction to a bunch of the why and how and what still needs to be down.
I think this post is maybe slightly too focused on “how to genetically edit for superbabies” to fully deserve its title. I hope we get a treatment of more selection-based methods sometime soon.
GeneSmith mentioned the high-quality discussion as a reason to post here, and I’m glad we’re able to offer that in return for high quality posts. I’m pleased to read this comment on ethical framing[1], much of this thread on power-seeking risks, this thread on low-hanging fruit/pleiotropy and this thread on predictor quality.
Thanks GeneSmith and kman! I hope that we can get more funding for these projects (I am considering spending a significant chunk of my time trying to make that happen)
I mostly appreciated it for the review of the ethical landscape, though the messaging considerations are also. important. I would value more threads that engaged with the ethics on the object level
Yes, the two other approaches not really talked about in this thread that could also lead to superbabies are iterated meiotic selection and genome synthesis.
Both have advantages over editing (you don’t need to have such precise knowledge of causal alleles with iterated meiotic selection or with genome synthesis), but my impression is they’re both further off than an editing approach.
Curated. Genetically enhanced humans are my best guess for how we achieve existential safety. (Depending on timelines, they may require a coordinated slowdown to work). This post is a pretty readable introduction to a bunch of the why and how and what still needs to be down.
I think this post is maybe slightly too focused on “how to genetically edit for superbabies” to fully deserve its title. I hope we get a treatment of more selection-based methods sometime soon.
GeneSmith mentioned the high-quality discussion as a reason to post here, and I’m glad we’re able to offer that in return for high quality posts. I’m pleased to read this comment on ethical framing[1], much of this thread on power-seeking risks, this thread on low-hanging fruit/pleiotropy and this thread on predictor quality.
Thanks GeneSmith and kman! I hope that we can get more funding for these projects (I am considering spending a significant chunk of my time trying to make that happen)
I mostly appreciated it for the review of the ethical landscape, though the messaging considerations are also. important. I would value more threads that engaged with the ethics on the object level
Yes, the two other approaches not really talked about in this thread that could also lead to superbabies are iterated meiotic selection and genome synthesis.
Both have advantages over editing (you don’t need to have such precise knowledge of causal alleles with iterated meiotic selection or with genome synthesis), but my impression is they’re both further off than an editing approach.
I’d like to write more about both in the future.