Before trusting the rat data, I’d want to investigate how similar their reaction to MDMA is to humans. When I did the comparison with ketamine I found out there is no known anesthetic dose of ketamine in mice and rats, you always combine it with another drug, which makes me think rats+mice are not useful models of ketamine’s effects in humans.
Before trusting the rat data, I’d want to investigate how similar their reaction to MDMA is to humans. When I did the comparison with ketamine I found out there is no known anesthetic dose of ketamine in mice and rats, you always combine it with another drug, which makes me think rats+mice are not useful models of ketamine’s effects in humans.