Anyone have a source for a summary of full life extension testing/supplementation regime?
Thiel?Kurzweil?
I’ve let things slide for a while, and want to get back on track with a full regime, including hormones and pharmaceuticals. I’m thinking cardiovascular, blood sugar, hormone, and neuroprotection.
I would not recommend hormones. Beware of Algernon’s law—if a simple biochemical tweak were always helpful, it’d probably already be that way. In particular a lot of things that try to work against ‘aging’ as opposed to specific dysfunctions will probably cause cancer. Thiel is a particular offender there, he recently started taking HGH with the justification “we’ll probably have cancer licked in a decade or two”. I read that statement to some people in my lab, where it provoked universal laughter.
The longer you live, and especially the longer you remain healthy, the more evolutionarily fit you are. At least insofar as it doesn’t funge against other traits evolution cares even more about, there’s every reason to think evolution has optimized your machinery for longevity. We might find the non-helpful side of the tradeoff to actually be beneficial to modern human eyes even if they’re horrible evolutionarily, like an ideal one would be “doubles your lifespan, makes you infertile”, but there won’t be anything evolution would see as a free lunch or a good tradeoff.
CellBioGuy attributed the “cancer licked in a decade or two” prediction to Thiel, not Kurzweil, do you actually have a source for it from Kurzweil? And does he have any particular reasons for stating it? Because even as someone on board with the singularity thing, that sounds like an insane pipe dream.
A couple of remarks to expand on RowanE’s points for anyone who may be skeptical that evolution cares at all about longevity past (something like) typical childrearing age:
Men (but not women) can continue to father children pretty much as long as they live.
Children may receive some support from extended families; the longer (e.g.) grandparents remain alive and healthy, the better for them (hence for their genes, which overlap a lot with the grandparents’).
I bet most things that make you more likely still to be alive at 80 also make you likely to be healthier (hence more useful to your children) at 30.
This is all true. However buyandbuydavis has a point. Evolution optimizes for offspring and longevity is only selected for as a means to that end. When you selectively breed and mutate fruit flies and nematodes for lifespan over hundreds of generations you can double or triple them, universally at the expense of total offspring. Granted mammals are much more k selected, putting lots of effort into a few offspring, than those r selected species that throw hundreds or even thousands of eggs to the wind per generation so lifespan does matter at least some to us and we probably already lie somewhere along that evolutionary axis away from the flies. But you can still see how there might be some tension between the two optimizations and we’re certainly not perfectly optimized for longevity.
That doesnt change my assessment that within any given existing evolved tuned organism a lot of the evidence ive seen suggests that mucking with hormone levels exogenously (as opposed to endogenously through general health activity diet etc) to try to keep energy or cell division or whatever up in the absence of an existing pathology of that hormone system will probably increase cancer rates.
Theres actually a promising line of research on a substance being developed by one of the scientific grandaddies of my current metabolism research that appears to be broadly neuroprotective via messing with regulation of aerobic respiration, something that also goes weird in muscles with age. I greatly look forward to seeing if it increases tumor rates too [there are biochemical mechanistic reasons i think it might] or if that particular dysregulation is something you can attack without nasty side effects (though i gotta say i would take a raised cancer risk to hold off alzheimers or parkinsonism or traumatic brain injury any day).
Start with medical tests for cholesterol, blood pressure, vitamin D, magnesium, diabetes and anything else your doctor recommends based on your age, family and disease history.
I don’t know if this is what you meant by “summary”, but Kurzweil’s book (co-written with some homeopath) Transcend (Amazon) is his most up-to-date effort. I’ve read it mostly and it seems well researched and also explains the science behind its recommendations.
I also thought I’d mention that there are now certain compounds (Wikipedia) which show some evidence of initiating telomerase production in adult humans. If this drug works as well in humans as it has been shown to work in mice, it should significantly increase your healthspan.
Anyone have a source for a summary of full life extension testing/supplementation regime?
Thiel?Kurzweil?
I’ve let things slide for a while, and want to get back on track with a full regime, including hormones and pharmaceuticals. I’m thinking cardiovascular, blood sugar, hormone, and neuroprotection.
I would not recommend hormones. Beware of Algernon’s law—if a simple biochemical tweak were always helpful, it’d probably already be that way. In particular a lot of things that try to work against ‘aging’ as opposed to specific dysfunctions will probably cause cancer. Thiel is a particular offender there, he recently started taking HGH with the justification “we’ll probably have cancer licked in a decade or two”. I read that statement to some people in my lab, where it provoked universal laughter.
The key question: helpful, for what?
There’s no reason to think Evolution has optimized my machinery for longevity.
As for giggles, I’ll bet on Kurzweil’s predictions over the people in your lab.
The longer you live, and especially the longer you remain healthy, the more evolutionarily fit you are. At least insofar as it doesn’t funge against other traits evolution cares even more about, there’s every reason to think evolution has optimized your machinery for longevity. We might find the non-helpful side of the tradeoff to actually be beneficial to modern human eyes even if they’re horrible evolutionarily, like an ideal one would be “doubles your lifespan, makes you infertile”, but there won’t be anything evolution would see as a free lunch or a good tradeoff.
CellBioGuy attributed the “cancer licked in a decade or two” prediction to Thiel, not Kurzweil, do you actually have a source for it from Kurzweil? And does he have any particular reasons for stating it? Because even as someone on board with the singularity thing, that sounds like an insane pipe dream.
A couple of remarks to expand on RowanE’s points for anyone who may be skeptical that evolution cares at all about longevity past (something like) typical childrearing age:
Men (but not women) can continue to father children pretty much as long as they live.
Children may receive some support from extended families; the longer (e.g.) grandparents remain alive and healthy, the better for them (hence for their genes, which overlap a lot with the grandparents’).
I bet most things that make you more likely still to be alive at 80 also make you likely to be healthier (hence more useful to your children) at 30.
This is all true. However buyandbuydavis has a point. Evolution optimizes for offspring and longevity is only selected for as a means to that end. When you selectively breed and mutate fruit flies and nematodes for lifespan over hundreds of generations you can double or triple them, universally at the expense of total offspring. Granted mammals are much more k selected, putting lots of effort into a few offspring, than those r selected species that throw hundreds or even thousands of eggs to the wind per generation so lifespan does matter at least some to us and we probably already lie somewhere along that evolutionary axis away from the flies. But you can still see how there might be some tension between the two optimizations and we’re certainly not perfectly optimized for longevity.
That doesnt change my assessment that within any given existing evolved tuned organism a lot of the evidence ive seen suggests that mucking with hormone levels exogenously (as opposed to endogenously through general health activity diet etc) to try to keep energy or cell division or whatever up in the absence of an existing pathology of that hormone system will probably increase cancer rates.
Theres actually a promising line of research on a substance being developed by one of the scientific grandaddies of my current metabolism research that appears to be broadly neuroprotective via messing with regulation of aerobic respiration, something that also goes weird in muscles with age. I greatly look forward to seeing if it increases tumor rates too [there are biochemical mechanistic reasons i think it might] or if that particular dysregulation is something you can attack without nasty side effects (though i gotta say i would take a raised cancer risk to hold off alzheimers or parkinsonism or traumatic brain injury any day).
Remember the 80⁄20 rule. Don’t over-optimize; it could be expensive and dangerous.
At least get your diet in line before you worry too much about pharmaceuticals.
Start with medical tests for cholesterol, blood pressure, vitamin D, magnesium, diabetes and anything else your doctor recommends based on your age, family and disease history.
I don’t know if this is what you meant by “summary”, but Kurzweil’s book (co-written with some homeopath) Transcend (Amazon) is his most up-to-date effort. I’ve read it mostly and it seems well researched and also explains the science behind its recommendations.
I also thought I’d mention that there are now certain compounds (Wikipedia) which show some evidence of initiating telomerase production in adult humans. If this drug works as well in humans as it has been shown to work in mice, it should significantly increase your healthspan.
Well...
Oh.