In the hospital, we usually give 1g IV for any real pain. I don’t think the notion that giving more of a painkiller would produce a stronger effect is particularly controversial!
(Anecdotally, the IV route is somewhat more effective, even though the nominal bioavailability is the same as the oral route. It might be down to faster onset and the placebo aspect of assuming anything given by a drip is “stronger”)
Depends on the painkiller. For opioids, higher doses are usually more effective for analgesia. The general approach is to start low, and then up-titrate until the patient reports the desired effect. Paracetamol vs NSAIDs vs Opioids makes it difficult to speak in broad strokes, they behave quite differently.
When it comes for over-the-counter pain killers like paracetamol, ibuprofen or aspirin there’s a dynamic of it not being advised to go over the recommended amount but you can do either paracetamol + ibuprofen or paracetamol + aspirin for added pain relief.
The kind of opioids where more is helpful seem to be need a doctor to prescribe them and are probably not for self dosing them to remove all the pain via the more dakka principle.
In the hospital, we usually give 1g IV for any real pain. I don’t think the notion that giving more of a painkiller would produce a stronger effect is particularly controversial!
(Anecdotally, the IV route is somewhat more effective, even though the nominal bioavailability is the same as the oral route. It might be down to faster onset and the placebo aspect of assuming anything given by a drip is “stronger”)
The general sense is that there’s no evidence that 2g is doing more than 1g, so it’s not that more of a painkiller always produces a stronger effect.
Just take more if you want a stronger effect, the More Dakka way does not seem a good heuristic for painkillers in general.
2g of Tylenol is an overdose. Surprisingly small overdoses can lead to fatal liver failure.
Depends on the painkiller. For opioids, higher doses are usually more effective for analgesia. The general approach is to start low, and then up-titrate until the patient reports the desired effect. Paracetamol vs NSAIDs vs Opioids makes it difficult to speak in broad strokes, they behave quite differently.
When it comes for over-the-counter pain killers like paracetamol, ibuprofen or aspirin there’s a dynamic of it not being advised to go over the recommended amount but you can do either paracetamol + ibuprofen or paracetamol + aspirin for added pain relief.
The kind of opioids where more is helpful seem to be need a doctor to prescribe them and are probably not for self dosing them to remove all the pain via the more dakka principle.