One thing does come to mind on this, but may well be way off target. It seems that a good model for most health and biology questions should fit with some pretty standard chemical reaction science. So ratios should matter a bit. Perhaps it’s as simple as at 1 pill the concentrations is just a poor ratio for the required reaction. As I understand it the current view is (per Gemini)
Inhibition of Sodium Channels: AM404 directly inhibits voltage-gated sodium channels (NaV1.7 and NaV1.8) in peripheral pain-sensing neurons (nociceptors). By blocking these channels, AM404 stops the generation of action potentials (pain messages) at the source before they are sent to the brain.
Perhaps the one pill simple does not allow the body (liver) to convert the paracetamol into enough AM404 to block enough neurons.
One thing does come to mind on this, but may well be way off target. It seems that a good model for most health and biology questions should fit with some pretty standard chemical reaction science. So ratios should matter a bit. Perhaps it’s as simple as at 1 pill the concentrations is just a poor ratio for the required reaction. As I understand it the current view is (per Gemini)
Inhibition of Sodium Channels: AM404 directly inhibits voltage-gated sodium channels (NaV1.7 and NaV1.8) in peripheral pain-sensing neurons (nociceptors). By blocking these channels, AM404 stops the generation of action potentials (pain messages) at the source before they are sent to the brain.
Perhaps the one pill simple does not allow the body (liver) to convert the paracetamol into enough AM404 to block enough neurons.