A lot of genes have multiplicative effects instead of additive effects. E.g. vegetable size is surprisingly log-normally distributed, not normally distributed, so I don’t think you should have a huge prior on normal here. See also one of my favorite papers of all time “Log-Normal Distributions Across The Sciences”.
A lot of genes have multiplicative effects instead of additive effects. E.g. vegetable size is surprisingly log-normally distributed, not normally distributed, so I don’t think you should have a huge prior on normal here. See also one of my favorite papers of all time “Log-Normal Distributions Across The Sciences”.