Mostly this makes me sad that no one has decided to manufacture the FDA-approved Lyme vaccine LYMErix, whose patent expired in 2014.
It seems like LYMErix is basically the OspA lipoprotein + alum (aluminum hydroxide) as adjuvant. OspA lipoprotein is readily commercially available and on the page they both tell you about which adjuvant the vaccine is conjugated with and allow you to order the protein with a conjugation with a free form field.
That suggest it’s relatively easy for someone with access to a clean room and the lab skills to order the materials and mix them together.
It’s conveniently also a relatively small protein which means that it should be possible to also order subparts of it if someone wants to do something more thoughtful then just repeating the old formula.
It seems like LYMErix is basically the OspA lipoprotein + alum (aluminum hydroxide) as adjuvant. OspA lipoprotein is readily commercially available and on the page they both tell you about which adjuvant the vaccine is conjugated with and allow you to order the protein with a conjugation with a free form field.
That suggest it’s relatively easy for someone with access to a clean room and the lab skills to order the materials and mix them together.
It’s conveniently also a relatively small protein which means that it should be possible to also order subparts of it if someone wants to do something more thoughtful then just repeating the old formula.