“The evidence that bears on the question of the applicability of CR to humans then, is at present indirect. There is nonetheless a great deal of such indirect evidence, enough that we can say with an extremely high degree of confidence that CR will work in humans.”
I think most in the field agree on that. e.g.:
“”I’m positive that caloric restriction will work in humans to extend median life span,” Fontana says.”
http://pubs.acs.org/cen/science/87/8731sci2.html
A summary from the site wiki:
“The evidence that bears on the question of the applicability of CR to humans then, is at present indirect. There is nonetheless a great deal of such indirect evidence, enough that we can say with an extremely high degree of confidence that CR will work in humans.”
http://en.wiki.calorierestriction.org/index.php/Will_CR_Work_in_Humans%3F
Off the top of your head do you know what CR has been shown to work on thus far?
One of TT’s links says CR works in “mice, hamsters, dogs, fish, invertebrate animals, and yeast.”